Clinical Oncology
Volume 18, Issue 1 , Pages 52-59 , February 2006

Radical Radiotherapy For Bladder Cancer: Retrospective Analysis of a Series of 459 Patients Treated in an Italian Institution

  • S. Tonoli

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • ,
  • F. Bertoni

      Affiliations

    • Radiation Oncology Department, Policlinico di Modena, Modena, Italy
    • ,
  • A. De Stefani

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • ,
  • E. Vitali

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • ,
  • D. De Tomasi

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • ,
  • B. Caraffini

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • ,
  • A. Scheda

      Affiliations

    • Universitätsklinikum Mannheim, Institut für klinische Radiologie, Sektion Strahlentherapie, Mannheim, Germany
    • ,
  • M. Bertocchi

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • ,
  • A. Somensari

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • ,
  • M. Buglione

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • ,
  • S.M. Magrini

      Affiliations

    • Radiation Oncology Department, Brescia University and Istituto del Radio ‘O.Alberti’, Spedali Civili, Brescia, Italy
    • Corresponding Author InformationAuthor for correspondence: Professor Stefano M. Magrini, Radiation Oncology Department, Brescia University – Istituto del Radio ‘O.Alberti’, Spedali Civili, Piazzale Spedali Civili 1, I-25123 Brescia, Italy. Tel: +39-0303995271; Fax: +39-030396700

Received 2 November 2004 ,Revised 14 June 2005 ,Accepted 16 June 2005.

References 

  1. http://cancer.gov/cancerinfo/pdq/treatment/bladder/healthprofessional/#Section_39updated 6 March 2003 (last accessed 5 August 2005)
  2. Coppin C, Gospodarowicz M, James K, et al. Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. J Clin Oncol. 1996;14:2901–2907
  3. Duncan W, Quilty PM. The results of a series of 963 patients with transitional cell carcinoma of the urinary bladder primarily treated by radical megavoltage X-ray therapy. Radiother Oncol. 1986;7:299–310
  4. Goodman GB, Hislop TG, Elwood JM, et al. Conservation of bladder function in patients with invasive bladder cancer treated by definitive irradiation and selective cystectomy. Int J Radiat Oncol Biol Phys. 1981;569–573
  5. Blandy JP, England HR, Evans SW, et al. T3 bladder cancer: the case for salvage cystectomy. Br J Urol. 1980;52:506–510
  6. Jenkins BJ, Nauth-Misir RR, Martin JE, et al. The fate of G3pT1 bladder cancer. Br J Urol. 1989;64:608–610
  7. TNM classification of malignant tumors. 5th edn. New York: Wiley-Liss; 1997;
  8. Bloom HJG, Hendry NF, Wallace DM, et al. Treatment of T3 bladder cancer: controlled trial of pre-operative radiotherapy and radical cystectomy versus radical radiotherapy. Br J Urol. 1982;54:136–151
  9. Sell A, Jakobsen A, Nerstrom B. Treatment of advanced bladder cancer category T2, T3, T4a. Scand J Urol Nephrol. 1991;138(Suppl):193–201
  10. Sauer R, Birkenhake S, Kuhn R, et al. Efficacy of radiochemotherapy with platin derivatives compared to radiotherapy alone in organ-sparing treatment of bladder cancer. Int J Radiat Oncol Biol Phys. 1998;40:121–127
  11. Housset M, Maulard C, Chretien Y, et al. Combined radiation and chemotherapy for invasive transitional-cell carcinoma of the bladder: a prospective study. J Clin Oncol. 1993;11:2150–2157
  12. Tester W, Porter A, Asbell S, et al. Combined modality program with possible organ preservation for invasive bladder carcinoma: results of RTOG protocol 85-12. Int J Radiat Oncol Biol Phys. 1993;25:783–790
  13. Shipley WU, Winter KA, Kaufmann DS, et al. Initial results of RTOG 8903: Phase III trial of neoadjuvant chemotherapy in patients with invasive bladder cancer treated with selective bladder preservation by combined radiation therapy and chemotherapy. J Clin Oncol. 1998;16(Suppl 11):3576–3583
  14. Kachnic L, Kaufmann DS, Heney NM, et al. Bladder preservation by combined modality therapy for invasive bladder cancer. J Clin Oncol. 1997;15:1022–1029
  15. Tester W, Caplan R, Heaney J, et al. Neoadjuvant combined modality program with selective organ preservation for invasive bladder cancer: results of Radiation Therapy Oncology Group phase II trial 8802. J Clin Oncol. 1996;14:119–126
  16. Gospodarowicz MK, Hawkins NV, Rawlings GA, et al. Radical radiotherapy for muscle invasive transitional cell carcinoma of the bladder: failure analysis. J Urol. 1989;142:1448–1454
  17. Jenkins BJ, Martin JE, Baithun SI, et al. Prediction of response to radiotherapy in invasive bladder cancer. Br J Urol. 1990;65:345–348
  18. Greven KM, Solin LI, Hanks GE. Prognostic factors in patients with bladder cancer treated with definitive irradiation. Cancer. 1990;65:908–912
  19. Jahnson S, Pedersen J, Westman G, et al. Bladder carcinoma: A 20 year review of radical irradiation therapy. Radiother Oncol. 1991;22:111–117
  20. Fossa SD, Waehre H, Aass N, et al. Bladder cancer definitive radiation therapy of muscle-invasive bladder cancer. A retrospective analysis of 317 patients. Cancer. 1993;72:3036–3043
  21. Pollack A, Zagars GK, Swanson DA, et al. Muscle-invasive bladder cancer treated with external beam radiotherapy: prognostic factors. Int J Radiat Oncol Biol Phys. 1994;30:267–277
  22. Rodel C, Dunst J, Grabenbauer GG, et al. Radiotherapy is an effective treatment for high-risk T1 bladder cancer. Strahlenther Onkol. 2001;177:82–88
  23. Herr HW. Timing for cystectomy for superficial tumors. Urol Oncol. 2001;5:162–165
  24. Sengeløv L, von der Maase H. Radiotherapy in bladder cancer. Radiother Oncol. 1999;52:1–14
  25. Moonen L, v.d. Voet H, De Nijs R, et al. Muscle-invasive bladder cancer treated with external beam radiation: influence of total dose, overall treatment time and treatment interruptions on local control. Int J Radiat Oncol Biol Phys. 1998;42:525–530
  26. Salminen E. External beam radiation treatment of urinary bladder carcinoma. Acta Oncol. 1990;29:909–914
  27. Sengeløv L, Klintorp S, Harsteen H, et al. Treatment outcome following radiotherapy in elderly patients with bladder cancer. Radiother Oncol. 1997;44:53–58
  28. Scrimger RA, Murtha AD, Parliament MB, et al. Muscle-invasive transitional cell carcinoma of the urinary bladder: a population-based study of patterns of care and prognostic factors. Int J Radiat Oncol Biol Phys. 2001;51:23–30
  29. Hayter CR, Paszat LF, Groome PA, et al. The management and outcome of bladder carcinoma in Ontario. Cancer. 2000;89:142–151
  30. Borgaonkar S, Jain A, Bollina P, et al. Radical radiotherapy and salvage cystectomy as the primary management of transitional cell carcinoma of the bladder. Results following the introduction of a CT planning technique. Clin Oncol. 2002;14:141–147
  31. Santacaterina A, Settineri N, De Renzis C, et al. Muscle-invasive bladder cancer in elderly-unfit patients with concomitant illness: can a curative radiation therapy be delivered?. Tumori. 2002;88:390–394
  32. Gospodarowicz M. Radiotherapy and organ preservation in bladder cancer: are we ignoring the evidence?. J Clin Oncol. 2002;20:3048–3050
  33. Cowan RA, McBain CA, Ryder WD, et al. Radiotherapy for muscle-invasive carcinoma of the bladder: results of a randomized trial comparing conventional whole bladder with dose-escalated partial bladder radiotherapy. Int J Radiat Oncol Biol Phys. 2004;59:197–207

PII: S0936-6555(05)00296-7

doi: 10.1016/j.clon.2005.06.015

Clinical Oncology
Volume 18, Issue 1 , Pages 52-59 , February 2006

Article Tools