Clinical Oncology
Volume 18, Issue 7 , Pages 539-544 , September 2006

Palliative Radiotherapy Improves Pain and Reduces Functional Interference in Patients with Painful Bone Metastases: A Quality Assurance Study

  • J.S.Y. Wu

      Affiliations

    • Division of Radiation Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada
    • Corresponding Author InformationAuthor for correspondence: Dr Jackson Wu, University of Calgary, Tom Baker Cancer Centre, Department of Oncology, 1331 29th St NW, Calgary, Alberta T2N 4N2, Canada. Tel: +1-403-521-3095; Fax: +1-403-283-1651.
  • ,
  • G. Monk

      Affiliations

    • Department of Nursing, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada
  • ,
  • T. Clark

      Affiliations

    • Department of Nursing, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada
  • ,
  • J. Robinson

      Affiliations

    • Department of Psychosocial Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada
  • ,
  • B.J.C. Eigl

      Affiliations

    • Division of Medical Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada
  • ,
  • N. Hagen

      Affiliations

    • Division of Palliative Medicine, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada

Received 20 December 2005 ,Revised 17 March 2006 ,Accepted 9 May 2006.

References 

  1. Wu JS, Bezjak A, Chow E, Kirkbride P. Primary treatment endpoint following palliative radiotherapy for painful bone metastases: need for a consensus definition?. Clin Oncol (R Coll Radiol). 2002;14:70–77
  2. Wu JS, Wong R, Johnston M, Bezjak A, Whelan T. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys. 2003;55:594–605
  3. Sze WM, Shelley MD, Held I, Wilt TJ, Mason MD. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy—a systematic review of randomised trials. Clin Oncol (R Coll Radiol). 2003;15:345–352
  4. Wai MS, Mike S, Ines H, Malcolm M. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy—a systematic review of the randomised trials. Cochrane Database Syst Rev. 2004;2:CD004721
  5. Cleeland CS. Measurement of pain by subjective report. In:  Chapman CR,  Loeser JD editor. Advances in pain research and therapy. Issues in pain management. Vol. 12:New York: Raven Press; 1989;
  6. Cleeland CS, Nakamura Y, Mendoza TR, et al. Dimensions of the impact of cancer pain in a four country sample: new information from multidimensional scaling. Pain. 1996;67:267–273
  7. Bone Pain Trial Working Party . 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomised comparison with a multifraction schedule over 12 months of patient follow-up. Radiother Oncol. 1999;52:111–121
  8. Steenland E, Leer JW, van Houwelingen H, et al. The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study. Radiother Oncol. 1999;52:101–109
  9. Chow E, Wu J, Hoskin P, et al. International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol. 2002;64:275
  10. Pereira J, Otfinowski PB, Hagen N, et al. Alberta palliative care resource. 2nd edn. Calgary: Alberta Cancer Board; 2001;24–25
  11. Farrar JT, Berlin JA, Strom BL. Clinically important changes in acute pain outcome measures: a validation study. J Pain Symptom Manage. 2003;25:406–411
  12. Dworkin RH, Turk DC, Farrar JT, et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain. 2005;113:9–19
  13. McQuay H. Consensus on outcome measures for chronic pain trials. Pain. 2005;113:1–2
  14. Weinfurt KP, Li Y, Castel LD, et al. The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer. Ann Oncol. 2005;16:579–584
  15. van der Linden Y, Oort FJ, Leer JWH. Quality of life in patients with painful bone metastases: results from the randomized Dutch Bone Metastasis Study on single fraction versus multiple fraction radiotherapy. Eur J Cancer Supplements. 2005;3:368
  16. Chow E, Hruby G, Davis L, et al. Quality of life after local external beam radiation therapy for symptomatic bone metastases: a prospective evaluation. Supp Cancer Ther. 2004;1:179–184
  17. Hartsell WF, Scott CB, Bruner DW, et al. Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases. J Natl Cancer Inst. 2005;97:798–804
  18. Haddad P, Wilson P, Wong R, et al. The success of data collection in the palliative setting—telephone or clinic follow-up?. Support Care Cancer. 2003;11:555–559
  19. Chow E, Fung KW, Bradley N, et al. Review of telephone follow-up experience at the Rapid Response Radiotherapy Program. Support Care Cancer. 2005;13:549–553

PII: S0936-6555(06)00174-9

doi: 10.1016/j.clon.2006.05.003

Clinical Oncology
Volume 18, Issue 7 , Pages 539-544 , September 2006