Clinical Oncology
Volume 19, Issue 4 , Pages 260-264 , May 2007

Vitamin E Protects against the Development of Radiation-induced Pulmonary Fibrosis in Rats

  • N.S. Bese

      Affiliations

    • Department of Radiation Oncology, Cerrahpasa Medical School, Istanbul University, 34098 Cerrahpasa, Istanbul, Turkey
    • Corresponding Author InformationAuthor for correspondence: Nuran Senel Bese, Tutuncu Mehmet Efendi Caddesi, Dr Rifat Pasa Sok, Goztepe Konutlari 19/2 Goztepe 34730, Istanbul, Turkey. Tel: +90-212-414-30-98; Fax: +90-212-414-31-01
    • ,
  • F. Munzuroglu

      Affiliations

    • Department of Radiation Oncology, Cerrahpasa Medical School, Istanbul University, 34098 Cerrahpasa, Istanbul, Turkey
    • ,
  • B. Uslu

      Affiliations

    • Department of Histology and Embryology, Medical School, Marmara University, Istanbul, Turkey
    • ,
  • S. Arbak

      Affiliations

    • Department of Histology and Embryology, Medical School, Marmara University, Istanbul, Turkey
    • ,
  • G. Yesiladali

      Affiliations

    • Cerrahpasa Medical School, 34098 Cerrahpasa, Istanbul, Turkey
    • ,
  • N. Sut

      Affiliations

    • Department of Biostatistics, Cerrahpasa Medical School, Istanbul University, 34098 Cerrahpasa, Istanbul, Turkey
    • ,
  • T. Altug

      Affiliations

    • Department of Experimental Animal Breeding and Research Laboratory, Cerrahpasa Medical School, Istanbul University, 34098 Cerrahpasa, Istanbul, Turkey
    • ,
  • A. Ober

      Affiliations

    • Department of Radiation Oncology, Cerrahpasa Medical School, Istanbul University, 34098 Cerrahpasa, Istanbul, Turkey

Received 17 July 2006 ,Revised 1 December 2006 ,Accepted 11 December 2006.

References 

  1. Vujaskovic Z, Marks LB, Anscher MS. The physical parameters and molecular events associated with radiation-induced lung toxicity. Semin Radiat Oncol. 2000;10:296–307
  2. Stone HB, Coleman CN, Anscher MS, et al. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol. 2003;4:529–536
  3. Finkelstein JN, Johnston CJ, Baggs R, Rubin P. Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosis. Int J Radiat Oncol Biol Phys. 1994;28:621–631
  4. Rodeman HP, Bamberg M. Cellular basis of radiation-induced fibrosis. Radiother Oncol. 1995;35:83–90
  5. Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines post irradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 1995;33:99–109
  6. Anscher MS, Kong FM, Andrews K, et al. Plasma transforming growth factor beta 1 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 1998;41:1029–1035
  7. Fu XL, Huang H, Bentel G, et al. Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta. Int J Radiat Oncol Biol Phys. 2001;50:899–908
  8. Chen Y, Williams J, Ding I, et al. Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol. 2002;12(1 Suppl 1):26–33
  9. Poli G, Parola M. Oxidative damage and fibrogenesis. Free Radic Biol Med. 1997;22:287–305
  10. Harroon ZA, Raleigh JA, Greenberg CS. Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann Surg. 2000;231:137–147
  11. Vujaskovic Z, Anscher MS, Feng QF. Radiation-induced hypoxia may perpetuate late normal tissue injury. Int J Radiat Oncol Biol Phys. 2001;50:851–855
  12. Kang SK, Rabbani ZN, Folz RJ, et al. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. Int J Radiat Oncol Biol Phys. 2003;15:1056–1066
  13. Empley LR, Papp JD, Jewell LD, Fedorak RN. Mucosal protective effects of vitamin E and misoprotosol during acute radiation-induced enteritis in rats. Dig Dis Sci. 1992;37:205–214
  14. Lefaix JL, Delanian S, Vozenin MC, Leplat JJ, Tricaud Y, Martin M. Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study. Int J Radiat Oncol Biol Phys. 1999;43:839–847
  15. Delanian S, Balla-Mekias S, Lefaix JL. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J Clin Oncol. 1999;17:3283–3290
  16. Delanian S, Porcher R, Balla-Mekias S, Lefaix JL. Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis. J Clin Oncol. 2003;21:2545–2550
  17. Haddad P, Kalaghchi B, Amouzegar-Hashemi F. Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial. Radiother Oncol. 2005;77:324–326
  18. Dion MW, Hussey DH, Osborne JW. The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. Int J Radiat Oncol Biol Phys. 1989;17:101–107
  19. Sieter RM, Remick DG, Ward PA, et al. Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun. 1988;155:1230–1236
  20. Ashcoft T, Simpson J, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol. 1988;41:467–470
  21. Daniel WW. Biostatistics: a foundation for analysis in the health sciences. 6th edn. New York: John Wiley and Sons; 1995;273–312
  22. Wiegman EM, von Gameren MM, Kampinga HH, Szabó BG, Coppes RP. Post-irradiation dietary vitamin E does not affect the development of radiation-induced lung damage in rats. Radiother Oncol. 2004;72:67–70
  23. Aburto A, Britton WM. Effects and interactions of dietary levels of vitamins A and E and cholecalciferol in broiler chickens. Poult Sci. 1998;7:666–673
  24. Redlich CA, Rockwell S, Chung JS, Sikora AG, Kelley M, Mayne ST. Vitamin A inhibits radiation-induced pneumonitis in rats. J Nutr. 1998;128:1661–1664
  25. Mutlu-Turkoglu U, Erbil Y, Oztezcan S, Olgac V, Toker G, Uysal M. The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats. Life Sci. 2000;66:1905–1913
  26. Bairiati I, Meyer F, Gelinas M, et al. Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients. J Clin Oncol. 2005;23:5455–5457
  27. Bese NS, Umay C, Yildirim S, et al. The effects of tamoxifen on radiation-induced pulmonary fibrosis in Wistar albino rats: results of an experimental study. Breast. 2006;15:456–460
  28. Inoue T, Fujishima S, Ikeda E, et al. CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis. Eur Respir J. 2004;24:49–56
  29. Bese NS, Ozguroglu M, Kamberoglu K, Karahasanoglu T, Ober A. Pentoxifylline in the treatment of radiation-related pelvic insufficiency fractures of bone. Radiat Med. 2003;21:223–227
  30. Dion MW, Hussey DH, Doornbos JF, Viglotti AP, Wen B, Anderson B. Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis. Int J Radiat Oncol Biol Phys. 1990;19:401–407
  31. Werner-Wasik M, Madoc-Jones H. Trental (pentoxifylline) relieves pain from postirradiation fibrosis. Int J Radiat Oncol Biol Phys. 1993;25:757–758
  32. Koh WJ, Stelzer KJ, Peterson LM, et al. Effect of pentoxifylline on radiation-induced lung and skin toxicity in rats. Int J Radiat Oncol Biol Phys. 1995;31:71–77
  33. Ozturk B, Egehan I, Atavci S, Kitapci M. Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial. Int J Radiat Oncol Biol Phys. 2004;58:213–219

PII: S0936-6555(06)00436-5

doi: 10.1016/j.clon.2006.12.007

Clinical Oncology
Volume 19, Issue 4 , Pages 260-264 , May 2007

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