Clinical Oncology
Volume 19, Issue 3 , Pages 167-171 , April 2007

RADICALS (Radiotherapy and Androgen Deprivation in Combination after Local Surgery)

  • C. Parker

      Affiliations

    • Academic Unit of Radiotherapy and Oncology, Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
    • Corresponding Author InformationAuthor for correspondence: Chris Parker, Academic Unit of Radiotherapy and Oncology, Institute of Cancer Research, Downs Road, Sutton, Surrey SM2 5PT, UK. Tel: +44-208-661-3425.
    • ,
  • N. Clarke

      Affiliations

    • Salford Royal Hospitals NHS Trust, Salford M6 8HD, UK
    • ,
  • J. Logue

      Affiliations

    • Christie Hospital NHS Trust, Manchester M20 4BX, UK
    • ,
  • H. Payne

      Affiliations

    • Department of Oncology, UCH, 250 Euston Road, London NW1 2PQ, UK
    • ,
  • C. Catton

      Affiliations

    • Princess Margaret Hospital, 610 University Avenue, Toronto, ON, Canada M5G 2M9
    • ,
  • H. Kynaston

      Affiliations

    • Department of Urology, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK
    • ,
  • C. Murphy

      Affiliations

    • MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    • ,
  • R. Morgan

      Affiliations

    • MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    • ,
  • C. Morash

      Affiliations

    • University of Ottawa, The Ottawa Hospital General Campus, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6
    • ,
  • W. Parulekar

      Affiliations

    • National Cancer Institute of Canada (NCIC) Clinical Trials Group, 10 Stuart Street, Kingston, Ontario, Canada K7L 3N6
    • ,
  • M. Parmar

      Affiliations

    • MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    • ,
  • C. Savage

      Affiliations

    • National Cancer Institute of Canada (NCIC) Clinical Trials Group, 10 Stuart Street, Kingston, Ontario, Canada K7L 3N6
    • ,
  • J. Stansfeld

      Affiliations

    • PCaSO Prostate Cancer Network, PO Box 66, Emsworth, Hampshire PO10 7ZP, UK
    • ,
  • M. Sydes

      Affiliations

    • MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    • ,
  • (The RADICALS Trial Management Group)

Received 14 December 2006 ,Revised 22 December 2006 ,Accepted 9 January 2007.

References 

  1. Bolla M, van Poppel H, Collette L, et al. Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911). Lancet. 2005;366(9485):572–578
  2. Thompson IM, Tangen CM, Paradelo J, et al. Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial. Jama. 2006;296(19):2329–2335
  3. Bolla M, Collette L, Blank L, et al. Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial. Lancet. 2002;360(9327):103–106
  4. D'Amico AV, Manola J, Loffredo M, Renshaw AA, DellaCroce A, Kantoff PW. 6-Month androgen suppression plus radiation therapy vs radiation therapy alone for patients with clinically localized prostate cancer: a randomized controlled trial. Jama. 2004;292(7):821–827
  5. Lawton C, Winter K, Murray K, et al. Updated results of the phase III Radiation Therapy Oncology Group (RTOG) Trial 85-31 evaluating the potential benefit of androgen suppression following standard radiation therapy for unfavorable prognosis carcinoma of the prostate. Int J Radiat Oncol Biol Phys. 2001;49(4):937–946
  6. Eulau SM, Tate DJ, Stamey TA, Bagshaw MA, Hancock SL. Effect of combined transient androgen deprivation and irradiation following radical prostatectomy for prostatic cancer. Int J Radiat Oncol Biol Phys. 1998;41(4):735–740
  7. King CR, Presti JC, Gill H, Brooks J, Hancock SL. Radiotherapy after radical prostatectomy: does transient androgen suppression improve outcomes?. Int J Radiat Oncol Biol Phys. 2004;59(2):341–347
  8. Katz MS, Zelefsky MJ, Venkatraman ES, Fuks Z, Hummer A, Leibel SA. Predictors of biochemical outcome with salvage conformal radiotherapy after radical prostatectomy for prostate cancer. J Clin Oncol. 2003;21(3):483–489
  9. Hanks GE, Pajak TF, Porter A, et al. Phase III trial of long-term adjuvant androgen deprivation after neoadjuvant hormonal cytoreduction and radiotherapy in locally advanced carcinoma of the prostate: the Radiation Therapy Oncology Group Protocol 92-02. J Clin Oncol. 2003;21(21):3972–3978
  10. Wiltshire K, Brock K, Haider M, et al. Achieving a consensus definition for anatomic boundaries of the CTV (prostate bed): methods and observer reproducibility using MRI. Oral presentation: ASTRO 48th Annual Meeting, 5–9 November 2006, Philadelphia.

PII: S0936-6555(07)00005-2

doi: 10.1016/j.clon.2007.01.001

Clinical Oncology
Volume 19, Issue 3 , Pages 167-171 , April 2007

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