Clinical Oncology
Volume 19, Issue 6 , Pages 470-480, August 2007

The Genomics Revolution and Radiotherapy

  • C.M.L. West

      Affiliations

    • Academic Radiation Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    • Corresponding Author InformationAuthor for correspondence: C. M. L. West, Academic Radiation Oncology, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK. Tel: +44 161 446 8275.
    • ,
  • R.M. Elliott

      Affiliations

    • Academic Radiation Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    • ,
  • N.G. Burnet

      Affiliations

    • Academic Radiation Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    • University of Cambridge, Department of Oncology, Oncology Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK

Received 9 February 2007; accepted 28 February 2007.

Abstract 

The expansion of our knowledge through the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. These assays can be carried out in various clinical samples at the DNA (genome), RNA (transcriptome) or protein (proteome) level. There is a belief that this genomic revolution, i.e. sequencing of the human genome and developments in high-throughput technology, heralds a future of personalised medicine. For clinical oncology, this progress should increase the possibility of predicting individual patient responses to radiotherapy. This review highlights some of the work involving sparsely ionising radiation and the new technologies.

Key words: Genomics, predictive assays, radiobiology

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0936-6555(07)00536-5

doi:10.1016/j.clon.2007.02.016

Clinical Oncology
Volume 19, Issue 6 , Pages 470-480, August 2007

Article Tools