Clinical Oncology
Volume 19, Issue 8 , Pages 596-603 , October 2007

Cosmesis, Late Sequelae and Local Control after Breast-Conserving Therapy: Influence of Type of Tumour Bed Boost and Adjuvant Chemotherapy

  • A.N. Budrukkar

      Affiliations

    • Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
    • ,
  • R. Sarin

      Affiliations

    • Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
    • ,
  • S.K. Shrivastava

      Affiliations

    • Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
    • ,
  • D.D. Deshpande

      Affiliations

    • Department of Medical Physics, Tata Memorial Hospital, Parel, Mumbai, India
    • ,
  • K.A. Dinshaw

      Affiliations

    • Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
    • Corresponding Author InformationAuthor for correspondence: K. A. Dinshaw, Department of Radiation Oncology, Tata Memorial Centre, Dr. E Borges Marg, Parel, Mumbai 400012, India. Tel: +912224139318/146750; Fax: +912224168440/146937.

Received 12 November 2006 ,Revised 16 May 2007 ,Accepted 16 June 2007.

References 

  1. Blichert Toft M, Rose C, Anderson JA, et al. Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life table analysis. J Natl Cancer Inst Monogr. 1992;11:19–25
  2. Fisher B, Redmond C, Poisson R, et al. Eight years results of randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 1989;320(13):822–828
  3. Fisher B, Anderson S, Bryant J, et al. Twenty year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–1241
  4. Jacobson J, Danforth D, Cowman K, et al. Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med. 1995;332(14):907–911
  5. Sarrazin D, Le MG, Arriagada R, et al. Ten year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer. Radiother Oncol. 1989;14(3):177–184
  6. Van Dongen JA, Bartelink H, Fentiman IS, et al. Randomized clinical trial to assess the value of breast conserving therapy in stage I and II breast cancer. J Natl Cancer Inst Monogr. 1992;11:15–18
  7. Veronesi U, Banfi A, Salvadore B, et al. Breast conservation is the treatment of choice in small breast cancer: long term results of a randomized trial. Eur J Cancer. 1990;26(6):668–670
  8. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow up of a randomized study comparing breast conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347(16):1227–1232
  9. Abner A, Recht A, Vicini F, et al. Cosmetic results after surgery, chemotherapy and radiation therapy for early breast cancer. Int J Radiat Oncol Biol Phys. 1991;21(2):331–338
  10. Danoff BF, Goodman RL, Glick JH, Haller DG, Pajak TF. The effect of adjuvant chemotherapy on cosmesis and complications in patients with breast cancer treated by definitive irradiation. Int J Radiat Oncol Biol Phys. 1983;9:1625–1630
  11. Fowble B, Fein DA, Hanlon AL, et al. The impact of tamoxifen on breast recurrence, cosmesis, complications, and survival in estrogen receptor-positive early-stage breast cancer. Int J Radiat Oncol Biol Phys. 1996;35(4):669–677
  12. Olivotto IA, Rose MA, Osteen RT, et al. Late cosmetic outcome after conservative surgery and radiotherapy: analysis of causes of cosmetic failure. Int J Radiat Oncol Biol Phys. 1989;17(4):747–753
  13. Perez CA, Taylor ME, Halverson K, et al. Brachytherapy or electron beam boost in conservation therapy of carcinoma of the breast: a nonrandomized comparison. Int J Radiat Oncol Biol Phys. 1996;34(5):995–1007
  14. Ray GR, Fish VJ, Marmor JB, et al. Impact of adjuvant chemotherapy on cosmesis and complications in stages I and II carcinoma of the breast treated by biopsy and radiation therapy. Int J Radiat Oncol Biol Phys. 1984;10(6):837–841
  15. Taylor ME, Perez CA, Halverson KJ, et al. Factors influencing cosmetic results after conservation therapy for breast cancer. Int J Radiat Oncol Biol Phys. 1995;31(4):753–764
  16. Wazer DE, Kramer B, Schmid C, et al. Factors determining outcome in patients treated with interstitial implantation as a radiation boost for breast conservation therapy. Int J Radiat Oncol Biol Phys. 1997;39(2):381–393
  17. Vrieling C, Collette L, Fourquet A, et al. The influence of patient, tumour and treatment factors on the cosmetic results after breast-conserving therapy in the EORTC ‘boost vs. no boost’ trial. EORTC Radiotherapy and Breast Cancer Cooperative Groups. Radiother Oncol. 2000;55(3):219–232
  18. Vrieling C, Collette L, Fourquet A, et al. The influence of the boost in breast-conserving therapy on cosmetic outcome in the EORTC “boost versus no boost” trial. Int J Radiat Oncol Biol Phys. 1999;45(3):677–685
  19. Fourquet A, Campana F, Zafrani B, et al. Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. Int J Radiat Oncol Biol Phys. 1989;17:719–725
  20. Mansfield CM, Komarnicky LT, Schwartz GF, et al. Ten-year results in 1070 patients with stages I and II breast cancer treated by conservative surgery and radiation therapy. Cancer. 1995;75(9):2328–2336
  21. Polgar C, Fodor J, Orosz Z, et al. Electron and high-dose-rate brachytherapy boost in the conservative treatment of stage I–II breast cancer: first results of the randomized Budapest boost trial. Strahlenther Onkol. 2002;178(11):615–623
  22. Touboul E, Belkacemi Y, Lefranc JP, et al. Early breast cancer: influence of type of boost (electrons vs iridium-192 implant) on local control and cosmesis after conservative surgery and radiation therapy. Radiother Oncol. 1995;34(2):105–113
  23. Deore SM, Sarin R, Dinshaw KA, et al. Influence of dose-rate and dose per fraction on clinical outcome of breast cancer treated by external beam irradiation plus iridium-192 implants: analysis of 289 cases. Int J Radiat Oncol Biol Phys. 1993;26(4):601–606
  24. Sarin R, Dinshaw KA, Shrivastava SK, et al. Therapeutic factors influencing the cosmetic outcome and late complications in the conservative management of the early breast cancer. Int J Radiat Oncol Biol Phys. 1993;27(2):285–292
  25. Dinshaw KA, Budrukkar AN, Chinoy RF, et al. Profile of prognostic factors in 1022 Indian women with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2005;63(4):1132–1141
  26. Dinshaw KA, Sarin R, Budrukkar AN, et al. Safety and feasibility of breast conserving therapy in Indian women: two decades of experience at Tata Memorial Hospital. J Surg Oncol. 2006;94:105–113
  27. Danforth DN. Re: Safety and feasibility of breast conserving therapy in Indian women: two decades of experience at Tata Memorial by Dinshaw KA, Sarin R, Budrukkar AN, et al. J Surg Oncol. 2006;94:89–90
  28. Harris JR, Levene MB, Svensson G, et al. Analysis of cosmetic results following primary radiation therapy for stage I and II carcinoma of the breast. Int J Radiat Oncol Biol Phys. 1979;5(2):257–261
  29. Yarnold J, Ashton A, Bliss J, et al. Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial. Radiother Oncol. 2005;75:9–17
  30. Owen JR, Ashton A, Bliss JM, et al. Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial. Lancet Oncol. 2006;7:467–471
  31. Kaplan EL, Meier P. Nonparametric estimation for incomplete observations. J Am Stat Assoc. 1958;4:57–81
  32. Bartelink H, Horiot JC, Poortmans P, et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med. 2001;345(19):1378–1387
  33. De La Rochefordiere A, Abner AL, Silver B, et al. Are cosmetic results following conservative surgery and radiation therapy for early breast cancer dependent on techniques?. Int J Radiat Oncol Biol Phys. 1992;23(5):925–931
  34. Kurtz JM, Miralbell R. Radiation therapy and breast conservation: cosmetic results and complications. Semin Radiat Oncol. 1992;2(2):125–131
  35. Rose MA, Olivotto I, Cady B, et al. Conservative surgery and irradiation therapy for early breast cancer: long term cosmetic results. Arch Surg. 1989;124(2):153–157
  36. Poortmans P, Bartelink H, Horiot JC, et al. The influence of the boost technique on local control in breast conserving treatment in the EORTC ‘boost versus no boost’ randomised trial. Radiother Oncol. 2004;72:25–33
  37. Early Breast Cancer Trialists' Collaborative Group . Multi-agent chemotherapy for early breast cancer. Cochrane Database Syst Rev. 2002;1:CD000487
  38. Manning MA, Arthur DW, Schmidt-Ullrich RK, et al. Interstitial high-dose-rate brachytherapy boost: the feasibility and cosmetic outcome of a fractionated outpatient delivery scheme. Int J Radiat Oncol Biol Phys. 2000;48(5):1301–1306
  39. Hennequin C, Durdux C, Espie M, et al. High-dose-rate brachytherapy for early breast cancer: an ambulatory technique. Int J Radiat Oncol Biol Phys. 1999;45(1):85–90
  40. Van Limbergen E, Rijnders A, van der Schueren E, et al. Cosmetic evaluation of breast conserving treatment for mammary cancer. 2. A quantitative analysis of the influence of radiation dose, fractionation schedules and surgical treatment techniques on cosmetic results. Radiother Oncol. 1989;16(4):253–267

PII: S0936-6555(07)00678-4

doi: 10.1016/j.clon.2007.06.008

Clinical Oncology
Volume 19, Issue 8 , Pages 596-603 , October 2007

Article Tools

* Image Usage & Resolution