Clinical Oncology
Volume 19, Issue 9 , Pages 639-648 , November 2007

Screening for Rectal Cancer – Will it Improve Cure Rates?

  • E.M. Tweedle

      Affiliations

    • Division of Surgery and Oncology, School of Cancer Studies, Liverpool, UK
    • ,
  • P.S. Rooney

      Affiliations

    • Department of Colorectal Surgery, Royal Liverpool Hospital, Liverpool, UK
    • ,
  • A.J.M. Watson

      Affiliations

    • School of Clinical Sciences, The Henry Wellcome Laboratory, Nuffield Building, University of Liverpool, Liverpool, UK
    • Corresponding Author InformationAuthor for correspondence: A. J. M. Watson, School of Clinical Sciences, The Henry Wellcome Laboratory, Nuffield Building, University of Liverpool, Crown Street, Liverpool L69 3GE, UK. Tel: +44-151-794-6811; Fax: +44-151-794-6825.

Received 22 January 2007 ,Accepted 18 July 2007.

References 

  1. United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) . Handbook for the clinicopathological assessment, staging of colorectal cancer. London: UKCCCR; 1989;
  2. UK Cancer Research. http://infocancerresearchukorg/cancerstats/types/bowel/.
  3. Jeffreys M, Rachet B, McDowell S, Habib AG, Lepage C, Coleman MP. Survival from rectal and anal cancers in England and Wales, 1986–2001. Eur J Cancer. 2006;42:1434–1440
  4. Sant M, Aareleid T, Berrino F, et al. EUROCARE-3: survival of cancer patients diagnosed 1990–94 – results and commentary. Ann Oncol. 2003;14(Suppl. 5):v61–v118
  5. Gunderson LL, Sargent DJ, Tepper JE, et al. Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis. J Clin Oncol. 2004;22:1785–1796
  6. Krebs B, Kozelj M, Kavalar R, Gajzer B, Gadzijev EM. Prognostic value of additional pathological variables for long-term survival after curative resection of rectal cancer. World J Gastroenterol. 2006;12:4565–4568
  7. Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet. 1986;1(8496):1479–1482
  8. MacFarlane JK, Ryall RD, Heald RJ. Mesorectal excision for rectal cancer. Lancet. 1993;341(8843):457–460
  9. Pedersen KE, Elwood M. Current international developments in population screening for colorectal cancer. Aust N Z J Surg. 2002;72:507–512
  10. Rex DK. American College of Gastroenterology action plan for colorectal cancer prevention. Am J Gastroenterol. 2004;99:574–577
  11. Rex DK, Johnson DA, Lieberman DA, Burt RW, Sonnenberg A. Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology. Am J Gastroenterol. 2000;95:868–877
  12. Obrand DI, Gordon PH. Incidence and patterns of recurrence following curative resection for colorectal carcinoma. Dis Colon Rectum. 1997;40:15–24
  13. Scholefield JH, Steele RJ. Guidelines for follow up after resection of colorectal cancer. Gut. 2002;51(Suppl. 5):V3–V5
  14. Kjeldsen BJ, Kronborg O, Fenger C, Jorgensen OD. A prospective randomized study of follow-up after radical surgery for colorectal cancer. Br J Surg. 1997;84:666–669
  15. Ovaska J, Jarvinen H, Kujari H, Perttila I, Mecklin JP. Follow-up of patients operated on for colorectal carcinoma. Am J Surg. 1990;159:593–596
  16. Rex DK, Kahi CJ, Levin B, et al. Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and US Multi-Society Task Force on Colorectal Cancer. CA Cancer J Clin. 2006;56:160–167
  17. Nugent KP, Phillips RK. Rectal cancer risk in older patients with familial adenomatous polyposis and an ileorectal anastomosis: a cause for concern. Br J Surg. 1992;79:1204–1206
  18. Rodriguez-Bigas MA, Vasen HF, Pekka-Mecklin J, et al. Rectal cancer risk in hereditary nonpolyposis colorectal cancer after abdominal colectomy. International Collaborative Group on HNPCC. Ann Surg. 1997;225:202–207
  19. Johnson WR, McDermott FT, Hughes ES, Pihl EA, Milne BJ, Price AB. The risk of rectal carcinoma following colectomy in ulcerative colitis. Dis Colon Rectum. 1983;26:44–46
  20. National Institute for Health and Clinical Excellence (NICE) . Improving outcomes in colorectal cancer. Colorectal Dis. 2006 Nov;8(9):815
  21. Buess G. Review: transanal endoscopic microsurgery (TEM). J R Coll Surg Edinb. 1993;38:239–245
  22. Whitehouse PA, Tilney HS, Armitage JN, Simson JN. Transanal endoscopic microsurgery: risk factors for local recurrence of benign rectal adenomas. Colorectal Dis. 2006;8:795–799
  23. Bach S, Mortensen N. Analysis of national database for TEM resected rectal cancer. Colorectal Dis. 2006;8:815
  24. Tada M, Karita M, Yanai H, Takemoto T. Endoscopic therapy of early gastric cancer by strip biopsy. Gan To Kagaku Ryoho. 1988;15:1460–1465
  25. Conio M, Repici A, Demarquay JF, Blanchi S, Dumas R, Filiberti R. EMR of large sessile colorectal polyps. Gastrointest Endosc. 2004;60:234–241
  26. Hurlstone DP, Sanders DS, Cross SS, et al. Colonoscopic resection of lateral spreading tumours: a prospective analysis of endoscopic mucosal resection. Gut. 2004;53:1334–1339
  27. Tamura S, Nakajo K, Yokoyama Y, et al. Evaluation of endoscopic mucosal resection for laterally spreading rectal tumors. Endoscopy. 2004;36:306–312
  28. Atkin WS, Saunders BP. Surveillance guidelines after removal of colorectal adenomatous polyps. Gut. 2002;51(Suppl 5):V6–V9
  29. Stryker SJ, Wolff BG, Culp CE, Libbe SD, Ilstrup DM, MacCarty RL. Natural history of untreated colonic polyps. Gastroenterology. 1987;93:1009–1013
  30. Dunlop MG. Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz–Jeghers syndrome. Gut. 2002;51(Suppl 5):V21–V27
  31. Heiskanen I, Jarvinen HJ. Fate of the rectal stump after colectomy and ileorectal anastomosis for familial adenomatous polyposis. Int J Colorectal Dis. 1997;12:9–13
  32. Church J, Burke C, McGannon E, Pastean O, Clark B. Risk of rectal cancer in patients after colectomy and ileorectal anastomosis for familial adenomatous polyposis: a function of available surgical options. Dis Colon Rectum. 2003;46:1175–1181
  33. Van Duijvendijk P, Vasen HF, Bertario L, et al. Cumulative risk of developing polyps or malignancy at the ileal pouch–anal anastomosis in patients with familial adenomatous polyposis. J Gastrointest Surg. 1999;3:325–330
  34. Annie Yu HJ, Lin KM, Ota DM, Lynch HT. Hereditary nonpolyposis colorectal cancer: preventive management. Cancer Treat Rev. 2003;29:461–470
  35. Jarvinen HJ, Aarnio M, Mustonen H, et al. Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology. 2000;118:829–834
  36. Lynch HT. Is there a role for prophylactic subtotal colectomy among hereditary nonpolyposis colorectal cancer germline mutation carriers?. Dis Colon Rectum. 1996;39:109–110
  37. Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001;48:526–535
  38. Collins PD, Mpofu C, Watson AJ, Rhodes JM. Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease. Cochrane Database Syst Rev. 2006;2:CD000279
  39. Choi PM, Nugent FW, Schoetz DJ, Silverman ML, Haggitt RC. Colonoscopic surveillance reduces mortality from colorectal cancer in ulcerative colitis. Gastroenterology. 1993;105:418–424
  40. Oakley JR, Lavery IC, Fazio VW, Jagelman DG, Weakley FL, Easley K. The fate of the rectal stump after subtotal colectomy for ulcerative colitis. Dis Colon Rectum. 1985;28:394–396
  41. Carter MJ, Lobo AJ, Travis SP. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2004;53(Suppl 5):V1–V16
  42. Eaden JA, Mayberry JF. Guidelines for screening and surveillance of asymptomatic colorectal cancer in patients with inflammatory bowel disease. Gut. 2002;51(Suppl 5):V10–V12
  43. Atkin W. Options for screening for colorectal cancer. Scand J Gastroenterol. 2003;237(Suppl):13–16
  44. Hoff G, Sauar J, Vatn MH, et al. Polypectomy of adenomas in the prevention of colorectal cancer: 10 years' follow-up of the Telemark Polyp Study I. A prospective, controlled population study. Scand J Gastroenterol. 1996;31:1006–1010
  45. Newcomb PA, Norfleet RG, Storer BE, Surawicz TS, Marcus PM. Screening sigmoidoscopy and colorectal cancer mortality. J Natl Cancer Inst. 1992;84:1572–1575
  46. Selby JV, Friedman GD, Quesenberry CP, Weiss NS. Effect of fecal occult blood testing on mortality from colorectal cancer. A case-control study. Ann Intern Med. 1993;118:1–6
  47. Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med. 1993;329:1977–1981
  48. Muller AD, Sonnenberg A. Prevention of colorectal cancer by flexible endoscopy and polypectomy. A case–control study of 32,702 veterans. Ann Intern Med. 1995;123:904–910
  49. Singh H, Turner D, Xue L, Targownik LE, Bernstein CN. Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies. J Am Med Assoc. 2006;295:2366–2373
  50. Betes M, Munoz-Navas MA, Duque JM, et al. Use of colonoscopy as a primary screening test for colorectal cancer in average risk people. Am J Gastroenterol. 2003;98:2648–2654
  51. Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Chejfec G. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med. 2000;343:162–168
  52. Imperiale TF, Wagner DR, Lin CY, Larkin GN, Rogge JD, Ransohoff DF. Results of screening colonoscopy among persons 40 to 49 years of age. N Engl J Med. 2002;346:1781–1785
  53. Robinson MH, Hardcastle JD, Moss SM, et al. The risks of screening: data from the Nottingham randomised controlled trial of faecal occult blood screening for colorectal cancer. Gut. 1999;45:588–592
  54. Pickhardt PJ, Nugent PA, Mysliwiec PA, Choi JR, Schindler WR. Location of adenomas missed by optical colonoscopy. Ann Intern Med. 2004;141:352–359
  55. Herrinton LJ, Selby JV, Friedman GD, Quesenberry CP, Weiss NS. Case–control study of digital-rectal screening in relation to mortality from cancer of the distal rectum. Am J Epidemiol. 1995;142:961–964
  56. Rao VS, Ahmad N, Al-Mukhtar A, Stojkovic S, Moore PJ, Ahmad SM. Comparison of rigid vs flexible sigmoidoscopy in detection of significant anorectal lesions. Colorectal Dis. 2005;7:61–64
  57. Thoeni RF, Petras A. Detection of rectal and rectosigmoid lesions by double-contrast barium enema examination and sigmoidoscopy. Accuracy of technique and efficacy of standard overhead views. Radiology. 1982;142:59–62
  58. Wilking N, Petrelli NJ, Herrera-Ornelas L, Walsh D, Mittelman A. A comparison of the 25-cm rigid proctosigmoidoscope with the 65-cm flexible endoscope in the screening of patients for colorectal carcinoma. Cancer. 1986;57:669–671
  59. Winawer SJ, Miller C, Lightdale C, et al. Patient response to sigmoidoscopy. A randomized, controlled trial of rigid and flexible sigmoidoscopy. Cancer. 1987;60:1905–1908
  60. Single flexible sigmoidoscopy screening to prevent colorectal cancer: baseline findings of a UK multicentre randomised trial. Lancet. 2002;359(9314):1291–1300
  61. Segnan N, Senore C, Andreoni B, et al. Baseline findings of the Italian multicenter randomized controlled trial of “once-only sigmoidoscopy” — SCORE. J Natl Cancer Inst. 2002;94(23):1763–1772
  62. Gondal G, Grotmol T, Hofstad B, Bretthauer M, Eide TJ, Hoff G. The Norwegian Colorectal Cancer Prevention (NORCCAP) screening study: baseline findings and implementations for clinical work-up in age groups 50–64 years. Scand J Gastroenterol. 2003;38:635–642
  63. Doria-Rose VP, Levin TR, Selby JV, Newcomb PA, Richert-Boe KE, Weiss NS. The incidence of colorectal cancer following a negative screening sigmoidoscopy: implications for screening interval. Gastroenterology. 2004;127:714–722
  64. Brevinge H, Lindholm E, Buntzen S, Kewenter J. Screening for colorectal neoplasia with faecal occult blood testing compared with flexible sigmoidoscopy directly in a 55–56 years' old population. Int J Colorectal Dis. 1997;12:291–295
  65. Segnan N, Senore C, Andreoni B, et al. Randomized trial of different screening strategies for colorectal cancer: patient response and detection rates. J Natl Cancer Inst. 2005;97:347–357
  66. NHS Breast Screening Programme Statistics. http://www.cancerscreening.nhs.uk/breastscreen/statistics.html.
  67. Glick S. Double-contrast barium enema for colorectal cancer screening: a review of the issues and a comparison with other screening alternatives. Am J Roentgenol. 2000;174:1529–1537
  68. Rockey DC, Koch J, Yee J, McQuaid KR, Halvorsen RA. Prospective comparison of air-contrast barium enema and colonoscopy in patients with fecal occult blood: a pilot study. Gastrointest Endosc. 2004;60:953–958
  69. Kung JW, Levine MS, Glick SN, Lakhani P, Rubesin SE, Laufer I. Colorectal cancer: screening double-contrast barium enema examination in average-risk adults older than 50 years. Radiology. 2006;240:725–735
  70. Pickhardt PJ, Taylor AJ, Kim DH, Reichelderfer M, Gopal DV, Pfau PR. Screening for colorectal neoplasia with CT colonography: initial experience from the 1st year of coverage by third-party payers. Radiology. 2006;241:417–425
  71. Herzog P, Holtermuller KH, Preiss J, et al. Fecal blood loss in patients with colonic polyps: a comparison of measurements with 51chromium-labeled erythrocytes and with the Haemoccult test. Gastroenterology. 1982;83:957–962
  72. Mandel JS, Bond JH, Church TR, et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med. 1993;328(19):1365–1371
  73. Mandel JS, Church TR, Ederer F, Bond JH. Colorectal cancer mortality: effectiveness of biennial screening for fecal occult blood. J Natl Cancer Inst. 1999;91:434–437
  74. Hardcastle JD, Chamberlain JO, Robinson MH, et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet. 1996;348(9040):1472–1477
  75. Scholefield JH, Moss S, Sufi F, Mangham CM, Hardcastle JD. Effect of faecal occult blood screening on mortality from colorectal cancer: results from a randomised controlled trial. Gut. 2002;50:840–844
  76. Kronborg O, Fenger C, Olsen J, Jorgensen OD, Sondergaard O. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet. 1996;348(9040):1467–1471
  77. Moss SM, Hardcastle JD, Coleman DA, Robinson MH, Rodrigues VC. Interval cancers in a randomized controlled trial of screening for colorectal cancer using a faecal occult blood test. Int J Epidemiol. 1999;28:386–390
  78. Guittet L, Bouvier V, Mariotte N, et al. Comparison of a guaiac-based and an immunochemical fecal occult blood test in screening for colorectal cancer in a general average-risk population. Gut. 2007;56:210–214
  79. Rozen P, Knaani J, Samuel Z. Performance characteristics and comparison of two immunochemical and two guaiac fecal occult blood screening tests for colorectal neoplasia. Dig Dis Sci. 1997;42:2064–2071
  80. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319:525–532
  81. Brenner DE, Rennert G. Fecal DNA biomarkers for the detection of colorectal neoplasia: attractive, but is it feasible?. J Natl Cancer Inst. 2005;97(15):1107–1109
  82. Ahlquist DA, Skoletsky JE, Boynton KA, et al. Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel. Gastroenterology. 2000;119:1219–1227
  83. Imperiale TF, Ransohoff DF, Itzkowitz SH, Turnbull BA, Ross ME. Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N Engl J Med. 2004;351(26):2704–2714
  84. Wu GH, Wang YM, Yen AM, et al. Cost-effectiveness analysis of colorectal cancer screening with stool DNA testing in intermediate-incidence countries. BMC Cancer. 2006;6:136
  85. Wessex Colorectal Cancer Audit. Progress report number 3, 1996.
  86. Tappenden P, Chilcott JB, Eggington S, Patnick J, Sakai H, Karnon J. Option appraisal of population-based colorectal cancer screening in England. Gut. 2007;56:677–684

PII: S0936-6555(07)00721-2

doi: 10.1016/j.clon.2007.07.002

Clinical Oncology
Volume 19, Issue 9 , Pages 639-648 , November 2007

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