Clinical Oncology
Volume 20, Issue 6 , Pages 457-462 , August 2008

The Role of Postoperative Radiotherapy in Carcinoma of the Endometrium

  • A. Kong

      Affiliations

    • Radiotherapy Department, Royal Marsden Hospital, London SW3 6JJ, UK
    • ,
  • M. Powell

      Affiliations

    • Radiotherapy Department, St. Bartholomew's Hospital, London EC1, UK
    • ,
  • P. Blake

      Affiliations

    • Radiotherapy Department, Royal Marsden Hospital, London SW3 6JJ, UK
    • Corresponding Author InformationAuthor for correspondence: P. Blake, Radiotherapy Department, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

Received 21 February 2008 ,Accepted 26 March 2008.

References 

  1. Pisani P, Bray F, Parkin DM. Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer. 2002;97(1):72–81
  2. Gallup DG, Stock RJ. Adenocarcinoma of the endometrium in women 40 years of age or younger. Obstet Gynecol. 1984;64(3):417–420
  3. Rose PG. Endometrial carcinoma. N Engl J Med. 1996;335(9):640–649
  4. Kucera H, Vavra N, Weghaupt K. Benefit of external irradiation in pathologic stage I endometrial carcinoma: a prospective clinical trial of 605 patients who received postoperative vaginal irradiation and additional pelvic irradiation in the presence of unfavorable prognostic factors. Gynecol Oncol. 1990;38(1):99–104
  5. Lybeert ML, van Putten WL, Brolmann HA, Coebergh JW. Postoperative radiotherapy for endometrial carcinoma. Stage I. Wide variation in referral patterns but no effect on long-term survival in a retrospective study in the southeast Netherlands. Eur J Cancer. 1998;34(4):586–590
  6. Farias-Eisner RP, Berek JS. Gynecologic cancers. Manual of clinical oncology. 4th edn. Philadelphia: Lippincott Williams and Wilkins; 2000;
  7. Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual. 6th edn. Berlin: Springer; 2002;
  8. DiSaia PJ, Creasman WT, Boronow RC, Blessing JA. Risk factors and recurrent patterns in stage I endometrial cancer. Am J Obstet Gynecol. 1985;151(8):1009–1015
  9. Eltabbakh GH, Piver MS, Hempling RE, Shin KH. Excellent long-term survival and absence of vaginal recurrences in 332 patients with low-risk stage I endometrial adenocarcinoma treated with hysterectomy and vaginal brachytherapy without formal staging lymph node sampling: report of a prospective trial. Int J Radiat Oncol Biol Phys. 1997;38(2):373–380
  10. Keys HM, Roberts JA, Brunetto VL, et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004;92(3):744–751
  11. Creutzberg CL, van Putten WL, Koper PC, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet. 2000;355(9213):1404–1411
  12. Creutzberg CL. Lymphadenectomy in apparent early-stage endometrial carcinoma: do numbers count?. J Clin Oncol. 2005;23(16):3653–3655
  13. Kitchener HC, RC, Swart AMC, Amos CL. A study in the treatment of endometrial cancer: a randomised trial of lymphadenectomy in the treatment of endometrial cancer. In: 14th International meeting of the European society of gynaecological oncology, Instanbul, 28 September 2005.
  14. Fujimoto T, Nanjyo H, Nakamura A, et al. Para-aortic lymphadenectomy may improve disease-related survival in patients with multipositive pelvic lymph node stage IIIc endometrial cancer. Gynecol Oncol. 2007;107(2):253–259
  15. Aalders J, Abeler V, Kolstad P, Onsrud M. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients. Obstet Gynecol. 1980;56(4):419–427
  16. Soderini A, AJ , Sardi JE. Role of adjuvant radiotherapy (RT) in intermediate risk (1b G2-3-1C) endometrioid carcinoma (EC) after extended staging surgery (ESS). Preliminary reports of a randomised trial. Int J Gynecol Cancer. 2003;13(Suppl 1):[abstract P0147:78]
  17. Kong A, Simera I, Collingwood M, Williams C, Kitchener H. Adjuvant radiotherapy for stage I endometrial cancer: systematic review and meta-analysis. Ann Oncol. 2007;18(10):1595–1604
  18. Piver MS, Yazigi R, Blumenson L, Tsukada Y. A prospective trial comparing hysterectomy, hysterectomy plus vaginal radium, and uterine radium plus hysterectomy in stage I endometrial carcinoma. Obstet Gynecol. 1979;54(1):85–89
  19. Morrow CP, Bundy BN, Kurman RJ, et al. Relationship between surgical–pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol. 1991;40(1):55–65
  20. Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group study. Cancer. 1987;60(Suppl 8):2035–2041
  21. Maggi R, Lissoni A, Spina F, et al. Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: results of a randomised trial. Br J Cancer. 2006;95(3):266–271
  22. Dunton CJ, Pfeifer SM, Braitman LE, Morgan MA, Carlson JA, Mikuta JJ. Treatment of advanced and recurrent endometrial cancer with cisplatin, doxorubicin, and cyclophosphamide. Gynecol Oncol. 1991;41(2):113–116
  23. Burke TW, Stringer CA, Morris M, et al. Prospective treatment of advanced or recurrent endometrial carcinoma with cisplatin, doxorubicin, and cyclophosphamide. Gynecol Oncol. 1991;40(3):264–267
  24. Aapro MS, van Wijk FH, Bolis G, et al. Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group. Ann Oncol. 2003;14(3):441–448
  25. Thigpen JT, Brady MF, Homesley HD, et al. Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2004;22(19):3902–3908
  26. De Palo G, Mangioni C, Periti P, Del Vecchio M, Marubini E. Treatment of FIGO (1971) stage I endometrial carcinoma with intensive surgery, radiotherapy and hormonotherapy according to pathological prognostic groups. Long-term results of a randomised multicentre study. Eur J Cancer. 1993;29A(8):1133–1140
  27. Thigpen JT, Brady MF, Alvarez RD, et al. Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol. 1999;17(6):1736–1744
  28. Thigpen T, Brady MF, Homesley HD, Soper JT, Bell J. Tamoxifen in the treatment of advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2001;19(2):364–367
  29. Whitney CW, Brunetto VL, Zaino RJ, et al. Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004;92(1):4–9
  30. Creutzberg CL, van Putten WL, Warlam-Rodenhuis CC, et al. Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: the Postoperative Radiation Therapy in Endometrial Carcinoma Trial. J Clin Oncol. 2004;22(7):1234–1241
  31. Kwon JS, Abrams J, Sugimoto A, Carey MS. Is adjuvant therapy necessary for Stage IA and IB uterine papillary serous carcinoma and clear cell carcinoma after surgical staging?. Int J Gynecol Cancer. 2007;in press

PII: S0936-6555(08)00163-5

doi: 10.1016/j.clon.2008.03.011

Clinical Oncology
Volume 20, Issue 6 , Pages 457-462 , August 2008

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