Clinical Oncology
Volume 20, Issue 8 , Pages 631-638 , October 2008

Improving Observer Variability in Target Delineation for Gastro-oesophageal Cancer—the Role of 18Ffluoro-2-deoxy-d-glucose Positron Emission Tomography/Computed Tomography

  • D. Vesprini

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    • ,
  • Y. Ung

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Canada
    • ,
  • R. Dinniwell

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    • ,
  • S. Breen

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    • ,
  • F. Cheung

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    • ,
  • D. Grabarz

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    • ,
  • J. Kamra

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Canada
    • ,
  • K. Mah

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Canada
    • ,
  • A. Mansouri

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • ,
  • G. Pond

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    • ,
  • K. Brock

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    • ,
  • G. Darling

      Affiliations

    • Department of Medicine, Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Canada
    • ,
  • J. Knox

      Affiliations

    • Department of Medicine, Division of Hematology Oncology, University Health Network, University of Toronto, Toronto, Canada
    • ,
  • M. Haider

      Affiliations

    • Department of Radiology, University Health Network, University of Toronto, Toronto, Canada
    • ,
  • R.K.S. Wong

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Canada
    • Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    • Corresponding Author InformationAuthor for correspondence: R. K. S. Wong, Department of Radiation Oncology, Princess Margaret Hospital, 5th Floor, Room 5-807, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9. Tel.: +1-416-946-2126; Fax: +1-416-946-4586.

Received 8 January 2008 ,Revised 28 May 2008 ,Accepted 10 June 2008.

References 

  1. van Vliet EP, Heijenbrok-Kal MH, Hunink MG, Kuipers EJ, Siersema PD. Staging investigations for oesophageal cancer: a meta-analysis. Br J Cancer. 2008;98(3):547–557
  2. Helmberger H. CT for local staging of esophageal cancer. Dis Esophagus. 1999;12(3):202–204
  3. Choi JY, Lee KH, Shim YM, et al. Improved detection of individual nodal involvement in squamous cell carcinoma of the esophagus by FDG PET. J Nucl Med. 2000;41(5):808–815
  4. Hansen CP, Oskarsson K, Mortensen D. Computed tomography for staging of oesophageal cancer. Ann Chir Gynaecol. 2000;89(1):14–18
  5. Wong WL, Chambers RJ. Role of PET/PET CT in the staging and restaging of thoracic oesophageal cancer and gastro-oesophageal cancer: a literature review. Abdom Imaging. 2008;33:183–190
  6. Gregoire V, Haustermans K, Geets X, Roels S, Lonneux M. PET-based treatment planning in radiotherapy: a new standard?. J Nucl Med. 2007;48(Suppl 1):68S–77S
  7. Knox JJ, Darling M, Guinidi M, et al. A phase II study to assess the efficacy of combined preoperative irinotecan (I)/cisplatin (C) chemotherapy and conformal radiotherapy (RT) followed by surgery for potentially resectable esophageal cancer. J Clin Oncol. 2004;22(14S):4063
  8. Tai P, Van Dyk J, Yu E, Battista J, Stitt L, Coad T. Variability of target volume delineation in cervical esophageal cancer. Int J Radiat Oncol Biol Phys. 1998;42(2):277–288
  9. Logue JP, Sharrock CL, Cowan RA, Read G, Marrs J, Mott D. Clinical variability of target volume description in conformal radiotherapy planning. Int J Radiat Oncol Biol Phys. 1998;41(4):929–931
  10. Hurkmans CW, Borger JH, Pieters BR, Russell NS, Jansen EP, Mijnheer BJ. Variability in target volume delineation on CT scans of the breast. Int J Radiat Oncol Biol Phys. 2001;50(5):1366–1372
  11. Yamamoto M, Nagata Y, Okajima K, et al. Differences in target outline delineation from CT scans of brain tumours using different methods and different observers. Radiother Oncol. 1999;50(2):151–156
  12. Leunens G, Menten J, Weltens C, Verstraete J, van der Schueren E. Quality assessment of medical decision making in radiation oncology: variability in target volume delineation for brain tumours. Radiother Oncol. 1993;29(2):169–175
  13. Coles CE, Hoole AC, Harden SV, et al. Quantitative assessment of inter-clinician variability of target volume delineation for medulloblastoma: quality assurance for the SIOP PNET 4 trial protocol. Radiother Oncol. 2003;69(2):189–194
  14. Weiss E, Richter S, Krauss T, et al. Conformal radiotherapy planning of cervix carcinoma: differences in the delineation of the clinical target volume. A comparison between gynaecologic and radiation oncologists. Radiother Oncol. 2003;67(1):87–95
  15. Hermans R, Feron M, Bellon E, Dupont P, Van den Bogaert W, Baert AL. Laryngeal tumor volume measurements determined with CT: a study on intra- and interobserver variability. Int J Radiat Oncol Biol Phys. 1998;40(3):553–557
  16. Rasch C, Eisbruch A, Remeijer P, et al. Irradiation of paranasal sinus tumors, a delineation and dose comparison study. Int J Radiat Oncol Biol Phys. 2002;52(1):120–127
  17. Ketting CH, Austin-Seymour M, Kalet I, et al. Automated planning target volume generation: an evaluation pitting a computer-based tool against human experts. Int J Radiat Oncol Biol Phys. 1997;37(3):697–704
  18. Mah K, Caldwell CB, Ung YC, et al. The impact of (18)FDG-PET on target and critical organs in CT-based treatment planning of patients with poorly defined non-small-cell lung carcinoma: a prospective study. Int J Radiat Oncol Biol Phys. 2002;52(2):339–350
  19. Van de Steene J, Linthout N, de Mey J, et al. Definition of gross tumor volume in lung cancer: inter-observer variability. Radiother Oncol. 2002;62(1):37–49
  20. Caldwell CB, Mah K, Ung YC, et al. Observer variation in contouring gross tumor volume in patients with poorly defined non-small-cell lung tumors on CT: the impact of 18FDG-hybrid PET fusion. Int J Radiat Oncol Biol Phys. 2001;51(4):923–931
  21. Cazzaniga LF, Marinoni MA, Bossi A, et al. Interphysician variability in defining the planning target volume in the irradiation of prostate and seminal vesicles. Radiother Oncol. 1998;47(3):293–296
  22. Fiorino C, Reni M, Bolognesi A, Cattaneo GM, Calandrino R. Intra- and inter-observer variability in contouring prostate and seminal vesicles: implications for conformal treatment planning. Radiother Oncol. 1998;47(3):285–292
  23. Pfau PR, Pham H, Ellis R, Das A, Isenberg G, Chak A. A novel use of endoscopic clips in the treatment planning for radiation therapy (XRT) of esophageal cancer. J Clin Gastroenterol. 2005;39(5):372–375
  24. Thomas E, Crellin A, Harris K, Swift S, Montefiore DS. The role of endoscopic ultrasound (EUS) in planning radiotherapy target volumes for oesophageal cancer. Radiother Oncol. 2004;73(2):149–151
  25. Seemann MD, Claussen CD. Hybrid 3D visualization of the chest and virtual endoscopy of the tracheobronchial system: possibilities and limitations of clinical application. Lung Cancer. 2001;32(3):237–246
  26. Kim SH, Lee JM, Eun HW, et al. Two- versus three-dimensional colon evaluation with recently developed virtual dissection software for CT colonography. Radiology. 2007;244(3):852–864
  27. Steenbakkers RJ, Duppen JC, Fitton I, et al. Reduction of observer variation using matched CT-PET for lung cancer delineation: a three-dimensional analysis. Int J Radiat Oncol Biol Phys. 2006;64(2):435–448
  28. Riegel AC, Berson AM, Destian S, et al. Variability of gross tumor volume delineation in head-and-neck cancer using CT and PET/CT fusion. Int J Radiat Oncol Biol Phys. 2006;65(3):726–732
  29. Breen SLPublicover J, De Silva Set al . Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers. Int J Radiat Oncol Biol Phys. 2007;68(3):763–770
  30. Konski A, Doss M, Milestone B, et al. The integration of 18-fluoro-deoxy-glucose positron emission tomography and endoscopic ultrasound in the treatment-planning process for esophageal carcinoma. Int J Radiat Oncol Biol Phys. 2005;61(4):1123–1128
  31. Moureau-Zabotto L, Touboul E, Lerouge D, et al. Impact of CT and 18F-deoxyglucose positron emission tomography image fusion for conformal radiotherapy in esophageal carcinoma. Int J Radiat Oncol Biol Phys. 2005;63(2):340–345
  32. Gondi V, Bradley K, Mehta M, et al. Impact of hybrid fluorodeoxyglucose positron-emission tomography/computed tomography on radiotherapy planning in esophageal and non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2007;67(1):187–195
  33. Vrieze O, Haustermans K, De Wever W, et al. Is there a role for FGD-PET in radiotherapy planning in esophageal carcinoma?. Radiother Oncol. 2004;73(3):269–275
  34. Leong T, Everitt C, Yuen K, et al. A prospective study to evaluate the impact of FDG-PET on CT-based radiotherapy treatment planning for oesophageal cancer. Radiother Oncol. 2006;78(3):254–261
  35. Patel DA, Chang ST, Goodman KA, et al. Impact of integrated PET/CT on variability of target volume delineation in rectal cancer. Technol Cancer Res Treat. 2007;6(1):31–36

PII: S0936-6555(08)00266-5

doi: 10.1016/j.clon.2008.06.004

Clinical Oncology
Volume 20, Issue 8 , Pages 631-638 , October 2008

Article Tools

* Image Usage & Resolution