Clinical Oncology
Volume 20, Issue 9 , Pages 683-690 , November 2008

Risk Stratification for Failure in Patients with Advanced Cervical Cancer after Concurrent Chemoradiotherapy: Another Way to Optimise Treatment Results

  • Ji-An Liang

      Affiliations

    • Department of Radiation Therapy and Oncology, China Medical University Hospital, Taiwan
    • School of Medicine, China Medical University, Taiwan
    • ,
  • Shang-Wen Chen

      Affiliations

    • Department of Radiation Therapy and Oncology, China Medical University Hospital, Taiwan
    • Department of Radiotherapy and Oncology, Taipei Medical University–Municipal Wan Fang Hospital, Taipei, Taiwan
    • Corresponding Author InformationAuthor for correspondence: Shang-Wen Chen, Department of Radiotherapy and Oncology, Taipei Medical University–Municipal Wan Fang Hospital, No.111, Section 3, Hsing-Long Road, Taipei 116, Taiwan. Tel: +886-2-28217378.
    • ,
  • Wei-Chun Chang

      Affiliations

    • School of Medicine, China Medical University, Taiwan
    • Department of Obstetrics and Gynecology, China Medical University Hospital, Taiwan
    • ,
  • Yao-Ching Hung

      Affiliations

    • School of Medicine, China Medical University, Taiwan
    • Department of Obstetrics and Gynecology, China Medical University Hospital, Taiwan
    • ,
  • Lian-Shung Yeh

      Affiliations

    • School of Medicine, China Medical University, Taiwan
    • Department of Obstetrics and Gynecology, China Medical University Hospital, Taiwan
    • ,
  • Shih-Neng Yang

      Affiliations

    • Department of Radiation Therapy and Oncology, China Medical University Hospital, Taiwan
    • School of Medicine, China Medical University, Taiwan
    • ,
  • Fang-Jen Lin

      Affiliations

    • Department of Radiation Therapy and Oncology, China Medical University Hospital, Taiwan
    • School of Medicine, China Medical University, Taiwan

Received 12 April 2008 ,Revised 16 June 2008 ,Accepted 17 June 2008.

References 

  1. Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med. 1999;340:1137–1143
  2. Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 1999;340:1143–1153
  3. Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med. 1999;340:1154–1161
  4. Whitney CW, Sause W, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB–IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecology Oncology Group and Southwest Oncology Group study. J Clin Oncol. 1999;17:1339–1348
  5. Pearcey R, Brundage M, Drouin P, et al. Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol. 2002;20:966–972
  6. Hong JH, Tsai CS, Lai CH, et al. Risk stratification of patients with advanced squamous cell carcinoma of cervix treated by radiotherapy alone. Int J Radiat Oncol Biol Phys. 2005;63:492–499
  7. Stehman FB, Bundy BN, DiSaia PJ, Keys HM, Larson JE, Fowler WC. Carcinoma of the cervix treated with radiotherapy. I. A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer. 1991;67:2776–2785
  8. O'Hara K, Tanaka YO, Tsunoda H, et al. Nonoperative assessment of nodal status for locally advanced cell carcinoma treated by radiotherapy with regard to patterns of treatment failure. Int J Radiat Oncol Biol Phys. 2003;55:354–361
  9. Tsai CS, Chang TC, Lai CH, et al. Preliminary report of using FDG-PET to detect extrapelvic lesions in cervical patients with enlarged pelvic lymph nodes on MRI/CT. Int J Radiat Oncol Biol Phys. 2004;58:1506–1512
  10. Stoeckli SJ, Mosna-Firlejczyk K, Goerres GW. Lymph node metastasis of squamous cell carcinoma from an unknown primary: impact of positron emission tomography. Eur J Nucl Med Mol Imaging. 2003;30:411–416
  11. Rotman M, Pajak TF, Choi K, et al. Prophylatic extended-field irradiation of para-aortic lymph nodes in stage IIB and bulky IB and IIA cervical cancer: ten-year treatment results of RTOG 79-20. JAMA. 1995;275:387–393
  12. Eifel PJ, Winter K, Morris M, et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of RTOG 90-01 trial. J Clin Oncol. 2004;22:872–880
  13. International Commission on Radiation Units and Measurements . ICRU report 38: dose and volume specification for reporting intracavitary therapy in gynecology. Bethesda: ICRU; 1985;
  14. Chen SW, Liang JA, Yeh LS, Yang SN, Shiau AC, Lin FJ. Comparative study of reference points by dosimetric analyses for late complications following uniform external radiotherapy and high-dose-rate brachytherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2004;60:663–671
  15. Petereit DG, Fowler JF. High-dose-rate brachytherapy: high-dose, high-tech, and high-results. Int J Radiat Oncol Biol Phys. 2003;55:1159–1161
  16. Nakano T, Kato S, Ohno T, et al. Long-term results of high-dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix. Cancer. 2005;103:92–101
  17. Chen SW, Liang JA, Hung YC, et al. Concurrent weekly cisplatin plus external beam radiotherapy and high-dose rate brachytherapy for advanced cervical cancer: a control cohort comparison with radiation alone on treatment outcome and complications. Int J Radiat Oncol Biol Phys. 2006;66(5):1370–1377
  18. Grigsby PW, Heydon K, Mutch DG, Kim RY, Eifel P. Long-term follow-up of RTOG 92-10: cervical cancer with positive para-aortic lymph nodes. Int J Radiat Oncol Biol Phys. 2001;51:982–987
  19. Grigsby PW, Singh AK, Siegel BA, Dehdashti F, Rader J, Zoberi I. Lymph node control in cervical cancer. Int J Radiat Oncol Biol Phys. 2004;59:706–712

PII: S0936-6555(08)00282-3

doi: 10.1016/j.clon.2008.06.007

Clinical Oncology
Volume 20, Issue 9 , Pages 683-690 , November 2008

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