Clinical Oncology
Volume 20, Issue 8 , Pages 606-612 , October 2008

Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor Expression are Associated with a Poor Prognosis in Patients with Nasopharyngeal Carcinoma Receiving Radiotherapy with Carbogen and Nicotinamide

  • Lu Xueguan

      Affiliations

    • Department of Radiation Oncology, Second Affiliated Hospital of Soochow University, Suzhou, China
    • Department of Radiation Oncology, Cancer Hospital of Fudan University, Shanghai, China
    • Corresponding Author InformationAuthor for correspondence: Xueguan Lu, Department of Radiation Oncology, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province, China. Tel: +86-512-67783916; Fax: +86-512-68284303.
    • ,
  • Wang Xiaoshen

      Affiliations

    • Department of Radiation Oncology, Cancer Hospital of Fudan University, Shanghai, China
    • ,
  • Zhang Yongsheng

      Affiliations

    • Department of Pathology, Second Affiliated Hospital of Soochow University, Suzhou, China
    • ,
  • Hu Chaosu

      Affiliations

    • Department of Radiation Oncology, Cancer Hospital of Fudan University, Shanghai, China
    • ,
  • Shen Chunying

      Affiliations

    • Department of Radiation Oncology, Cancer Hospital of Fudan University, Shanghai, China
    • ,
  • Feng Yan

      Affiliations

    • Department of Radiation Oncology, Cancer Hospital of Fudan University, Shanghai, China

Received 7 March 2008 ,Revised 2 July 2008 ,Accepted 3 July 2008.

References 

  1. Zhang L, Zhao C, Peng PJ, et al. Phase III study comparing standard radiotherapy with or without weekly oxaliplatin in treatment of locoregionally advanced nasopharyngeal carcinoma: preliminary results. J Clin Oncol. 2005;23:8461–8468
  2. Zhang EP, Lian PG, Cai KL, et al. Radiation therapy of nasopharyngeal carcinoma: prognostic factors based on a 10-year follow-up of 1302 patients. Int J Radiat Oncol Biol Phys. 1989;16:301–305
  3. Fandi A, Altun M, Azli N, et al. Nasopharyngeal cancer, epidemiology, staging and treatment. Semin Oncol. 1994;21:382–397
  4. Lee AW, Poon YF, Foo W, et al. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976–1985: overall survival and patterns of failure. Int J Radiat Oncol Biol Phys. 1992;23:261–270
  5. Yeh SH, Liu RS, Wu LC, et al. Fluorine-18 fluoromisonidazole tumour to muscle retention ratio for the detection of hypoxia in nasopharyngeal carcinoma. Eur J Nucl Med. 1996;23:1378–1383
  6. Fyles AW, Milosevic M, Wong R, et al. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol. 1998;48:149–156
  7. Rofstad EK, Sunfor K, Lyng H, et al. Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br J Cancer. 2000;83:354–359
  8. Gatenby RA, Kessler HB, Rosenblum JS, et al. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys. 1988;14:831–838
  9. Norsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation responses in advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 1996;41:31–39
  10. Sutherland RM, Ausserer WA, Murphy BJ, et al. Tumor hypoxia and heterogeneity: challenges and opportunities for the future. Semin Radiat Oncol. 1996;6:59–70
  11. Blancher C, Harris AL. The molecular basis of the hypoxia response pathway: tumor hypoxia as a therapy target. Cancer Metastasis Rev. 1998;17:187–194
  12. Wenger RH. Mammalian oxygen sensing, signaling and gene regulation. J Exp Biol. 2000;203:1253–1263
  13. Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995;92:5510–5514
  14. Huang LE, Arany Z, Livingston DM, et al. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit. J Biol Chem. 1996;271:32253–32259
  15. Semenza GL. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol. 2002;64:993–998
  16. Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Ann Rev Cell Dev Biol. 1999;15:551–578
  17. Jiang BH, Rue E, Wang GL, et al. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem. 1996;271:17771–17778
  18. Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830–5835
  19. Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia-inducible factor-1 alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer. 2003;97:1573–1581
  20. Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1 alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 2001;61:2911–2916
  21. Theodoropoulos VE, Lazaris AC, Sofras F, et al. Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol. 2004;46:200–208
  22. Hui EP, Chan ATC, Pezzella F, et al. Coexpression of hypoxia-inducible factors 1α and 2α, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Clin Cancer Res. 2002;8:2595–2604
  23. Chan CML, Ma BBY, Hui EP, et al. Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma — a prognostic evaluation and correlation with hypoxia inducible factor 1α and vascular endothelial growth factor. Oral Oncol. 2007;43:373–378
  24. Hoogsteen IJ, Marres HAM, Bussink J, et al. Tumor microenvironment in head and neck squamous cell carcinomas: predictive value and clinical relevance of hypoxic markers. A review. Head Neck. 2007;29:591–604
  25. Jones A, Fujiyama C, Blanche C, et al. Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in human bladder tumors and cell lines. Clin Cancer Res. 2001;7:1263–1272
  26. Gray MJ, Zhang J, Ellis LE, et al. HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 2005;24:3110–3120
  27. Li YH, Hu CF, Shao Q, et al. Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma. J Transl Med. 2008;6:1
  28. Kaanders JHAM, Wijffels KIEM, Marres HAM, et al. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Res. 2002;62:7066–7074
  29. Koukourakis MI, Giatromanolaki A, Sivridis E, et al. Hypoxia-inducible factor (HIF-1α and HIF-2α), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2002;53:1192–1202
  30. Sauter ER, Nesbit M, Watson JC, et al. Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res. 1999;5:775–782

PII: S0936-6555(08)00286-0

doi: 10.1016/j.clon.2008.07.001

Clinical Oncology
Volume 20, Issue 8 , Pages 606-612 , October 2008

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