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Clinical Oncology
Volume 21, Issue 2
, Pages 118-130
, March 2009
Optimising Care of Elderly Breast Cancer Patients: a Challenging Priority
References
- Breast cancer mortality patterns and time trends in 10 new EU member states: mortality declining in young women, but still increasing in the elderly. Int J Cancer. 2004;112:1056–1064
- Risk factors for breast cancer in elderly women. Am J Epidemiol. 2004;160:868–875
- . What threshold for adjuvant therapy in older breast cancer patients?. J Clin Oncol. 2000;18:1709–1717
- Breast cancer in elderly women: outcome as affected by age, tumour features, comorbidities and treatment approach. Clin Breast Cancer. 2006;7:59–66
- . The elderly: geriatric oncology finally deserving adequate attention. Eur J Cancer. 2007;43:2312–2314
- Individualised treatment of the older cancer patient: a decision analysis. J Am Geriatr Soc. 1990;58:61a
- . Management of cancer in the older person: a practical approach. Oncologist. 2000;5:224–237
- . Disease, disability, and age in cognitively intact seniors: results from the Canadian study of health and aging. J Gerontol. 1999;54A:M77–M82
- Daily Telegraph. 2 February 2008;
- . Cytotoxic therapy for the elderly with metastatic breast cancer: a review on safety, pharmacokinetics and efficacy. Eur J Cancer. 2007;43:1514–1528
- . The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. Arch Intern Med. 1990;150:841–845
- . Cancer in older persons: an international issue in an aging world. Semin Oncol. 2004;31:128–136
- Perspectives on comorbidity and cancer in older patients: approaches to expand the knowledge base. J Clin Oncol. 2001;19:1147–1157
- Breast cancer treatment of older women in integrated health care settings. J Clin Oncol. 2006;24:4377–4383
- Patterns of toxicity in older patients with breast cancer receiving adjuvant chemotherapy. Breast Cancer Res Treat. 2005;92:151–156
- Factors influencing treatment patterns of breast cancer patients age 75 and older. Crit Rev Oncol Hematol. 2003;46:121–126
- . Population-based assessment of hospitalizations for toxicity from chemotherapy in older women with breast cancer. J Clin Oncol. 2002;20:4636–4642
- . Tumour characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst. 2000;92:550–556
- Dealing with metastatic breast cancer in elderly women: results from a French study on a large cohort carried out by the ‘Observatory on Elderly Patients’. Ann Oncol. 2006;17:211–216
- Nutrition, cancer and aging: an annotated review. J Am Geriatr Soc. 1986;34:127–136
- . The predictive value of body protein for chemotherapy induced toxicity. Cancer. 2000;88:796–803
- . Age related variation in treatment and outcomes of patients with breast carcinoma. Cancer. 2000;88:369–374
- Cheung KL, Morgan DAL, Wong AWS, et al. Pattern of oestrogen receptor (ER)-positivity in elderly breast cancer: comparison with younger age. 10th Nottingham International Breast Cancer Conference, September 2007; abstract 0–35.
- . The role of surgery in the management of older women with breast cancer. Eur J Cancer. 2007;43:2253–2263
- . Incidence and predictors of low dose-intensity in adjuvant breast cancer chemotherapy: a nationwide study of community practices. J Clin Oncol. 2003;21:4524–4534
- Epirubicin plus tamoxifen versus tamoxifen alone in node-positive postmenopausal patients with breast cancer: a randomized trial of the International Collaborative Cancer Group. J Clin Oncol. 1999;17:1988–1998
- Nuzzo F, Perrone F, Labonia V, et al. Weekly docetaxel vs. CMF as adjuvant chemotherapy for elderly breast cancer patients: safety data from the ELDA trial. 14th European Cancer Conference, Barcelona, September 2007; poster 2034.
- Phase II study of oral vinorelbine in first-line advanced breast cancer chemotherapy. J Clin Oncol. 2003;21:35–40
- Underrepresentation of patients 65 years of age or older in cancer treatment trials. N Engl J Med. 1999;341:2061–2067
- . Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol. 2001;83:378–382
- Adjuvant chemotherapy in elderly patients with breast cancer: a survey of the Breast International Group. Ann Oncol. 2004;15:207–210
- Comorbidity and functional status are independent in older cancer patients. J Clin Oncol. 1998;16:1582–1587
- Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology study. J Clin Oncol. 2002;20:494–502
- Adjuvant therapy in the elderly. Making the right decision. J Clin Oncol. 2007;25:1870–1875
- Comprehensive geriatric assessment and its clinical impact on oncology. Eur J Cancer. 2007;43:2161–2169
- . Contribution of the geriatrician to the management of cancer in older patients. Eur J Cancer. 2007;43:2153–2160
- . Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;365:1687–1717
- . Clinical decision making in breast cancer: TAM and aromatase inhibitors for older patients – a jungle?. Eur J Cancer. 2007;43:2270–2278
- . The emerging role of aromatase inhibitors in the adjuvant management of breast cancer. Rev Recent Clin Trials. 2006;1:237–249
- Anastrazole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet. 2002;359:2131–2139
- Survival and safety of exemestane versus tamoxifen after 2–3 years of tamoxifen treatment (Intergroup Exemestane Study): a randomized controlled trial. Lancet. 2007;369:559–570
- Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG1-98. J Clin Oncol. 2007;25:486–492
- Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast cancer who complete 5 years of tamoxifen. J Clin Oncol. 2008;26:1948–1955
- . Aromatase inhibitors in adjuvant therapy of breast cancer: before, instead of, or beyond tamoxifen. J Clin Oncol. 2005;23:4850–4852
- on behalf of the H2H trial steering committee. The Head to Head trial: letrozole vs anastrozole as adjuvant treatment of postmenopausal patients with node positive breast cancer. J Clin Oncol. 2006;24(18S):582s;(abstract 10672)
- . Update on the MA.17 extended adjuvant trial. Best Pract Res Clin Endocrinol Metab. 2006;20(Suppl 1):S5–S13
- NSABP-42: a clinical trial to determine the efficacy of five years of letrozole compared with placebo in patients completing five years of hormonal therapy consisting of an aromatase inhibitor (AI) or tamoxifen followed by an AI in prolonging disease free survival in postmenopausal women with hormone receptor breast cancer. Clin Breast Cancer. 2006;7:416–421
- Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: a modelling analysis. J Natl Cancer Inst. 2008;100:642–648
- Endocrine
±
Surgical Therapy for Elderly women with Mammary cancer: the ESTEeM trial. Protocol version 2.0 (5 December 2006). - Phenotypes for endocrine resistance can by identified by RNA microarray of sequential biopsies and are more variable than those predicting for tumour response. Breast Cancer Res Treat. 2005;94(Suppl 1):S17;abstract 31
- The relative efficacy of neoadjuvant endocrine therapy vs. chemotherapy in postmenopausal women with ER positive breast cancer. Proc Am Soc Clin Oncol. 2004;22:519
- Is there an optimal duration of neoadjuvant therapy?. Breast Cancer Res Treat. 2004;88(Suppl 1):S36
- . Comparison of anastrozole vs tamoxifen alone and in combination as neoadjuvant treatment of estrogen receptor-positive (ER+) operable breast cancer in post-menopausal women: the IMPACT trial. Breast Cancer Res Treat. 2003;82(Suppl 1):S6
- Preoperative treatment of postmenopausal breast cancer patients with letrozole: a randomized double-blind multicenter study. Ann Oncol. 2001;12:1527–1532
- Letrozole inhibits tumour proliferation more effectively than tamoxifen, independent of HER1/2 expression status. Cancer Res. 2003;63:6523–6531
- Kuter I, Hegg R, Singer CF, et al. On behalf of the NEWEST investigators. Fulvestrant 500
mg vs 250
mg: first results from NEWEST, a randomized, phase II neoadjuvant trial in postmenopausal women with locally advanced, estrogen receptor-positive breast cancer. 30th Annual San Antonio Breast Cancer Symposium, 2007;abstract 23. - Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol. 2002;20:3386–3395
- Fulvestrant, formerly ICI 182780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol. 2002;20:3396–3403
- Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women. A prospective combined analysis of two multicentre trials. Cancer. 2003;98:229–238
- Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma. A prospectively planned combined survival analysis of two multicentre trials. Cancer. 2005;104:236–239
- Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT. J Clin Oncol. 2008;26:1664–1670
- Sainsbury R, on behalf of the ATAC Trialists Group. Anastrozole shows greater carryover effects compared with tamoxifen and resolution of fracture risk post treatment — data from ATAC at 100 months' median follow up. European Breast Cancer Conference, 2008;poster 263.
- Ellis G, Bone HG, Chlebowski R, et al. A phase 3 study of the effect of denosumab therapy on bone mineral density in women receiving aromatase inhibitors for nonmetastatic breast cancer. 30th Annual San Antonio Breast Cancer Symposium 2007; abstract 47.
- Schilder CM, Eggens PC, Boogerd W, et al. Neuropsychological sequelae of tamoxifen and exemestane after AC-chemotherapy in postmenopausal women with early breast cancer. Program and abstracts of the American Society of Clinical Oncology Annual Meeting, 2007;abstract 566.
- Memory impairments with adjuvant anastrozole versus tamoxifen in women with early-stage breast cancer. Menopause. 2007;14:995–998
- Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA. 2003;289:2651–2662
- A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med. 2005;353:2747–2757
- Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. J Natl Cancer Inst. 2005;97:1262–1271
- The benefits of letrozole in postmenopausal women with early stage breast cancer who have had five years of tamoxifen are independent of age. Breast Cancer Res Treat. 2006;100(Suppl 1):S23;abstract 102
- Factors affecting pharmacokinetic variability following doxorubicin and docetaxel-based therapy. Eur J Cancer. 2004;40:1170–1178
- . The effect of age on the early disposition of doxorubicin. Cancer Chemother Pharmacol. 2003;51:395–402
- . Toxicity and therapeutic response to chemotherapy in patients aged 70 years or older with advanced cancer. Am J Clin Oncol. 1996;19:371–374
- Mitoxantrone in elderly women with advanced breast cancer: a phase 2 study. Anticancer Res. 1995;15:2297–3000
- Disease-free survival advantage of weekly epirubicin plus tamoxifen versus tamoxifen alone as adjuvant treatment of operable, node-positive, elderly breast cancer patients: 6-year follow-up results of the French adjuvant study group 08 trial. J Clin Oncol. 2004;22:4622–4630
- Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer. J Clin Oncol. 2006;24:5381–5387
- Standard chemotherapy (CMF or AC) versus capecitabine in early-stage breast cancer patients aged 65 and older: results of CALGB/CTSU 49907. J Clin Oncol. 2008;26:abstract 507
- Slamon D, Mackey J, Robert N, et al. Role of anthracycline-based therapy in the adjuvant treatment of breast cancer: efficacy analyses determined by molecular subtypes of the disease. 30th Annual San Antonio Breast Cancer Symposium, 2007;abstract 13.
- ANZ Breast Cancer Trials Group. A randomized trial of capecitabine (C) given intermittently (IC) rather than continuously (CC) compared to classical CMF as first-line chemotherapy for advanced breast cancer (ABC). ASCO Annual Meeting Proc. 2007;25(18S):1031
- A randomised phase 2 study of capecitabine versus CMF as first line chemotherapy of breast cancer in women aged >55 years. Proc Am Soc Clin Oncol. 1998;103:abstract 398
- Safety and efficacy of two different doses of capecitabine in the treatment of advanced breast cancer in older women. J Clin Oncol. 2005;23:2155–2161
- First line gemcitabine versus epirubicin in postmenopausal women aged 60 or older with metastatic breast cancer: a multicentre, randomised phase 3 study. Ann Oncol. 2005;16:899–908
- Single agent vinorelbine as first line chemotherapy in elderly patients with advanced breast cancer. Anticancer Res. 2003;23:1657–1664
- Which benefit from adding gemcitabine to vinorelbine in elderly (>70 years) women with metastatic breast cancer? Early interruption of a phase 2 study. Ann Oncol. 2007;18:58–63
- Debled M, Madranges N, Mertens C, et al. Retrospective analysis of chemotherapy choices and overall survival according to treatment in 96 patients >75 years old with metastatic breast cancer. 6th European Breast Cancer Conference, 2008; poster 415.
- . Greater risks of chemotherapy toxicity in elderly patients with cancer. J Support Oncol. 2003;1(4 Suppl 2):18–24
- . General guidelines for the management of older patients with cancer. Oncology. 2000;14:221–227
- Vulnerable and frail elderly: an approach to the management of the main tumour types. Eur J Cancer. 2008;44:488–493
- International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency. Eur J Cancer. 2007;43:14–34
- The impact of new European Organisation for Research and Treatment of Cancer guidelines on the use of granulocyte colony-stimulating factor on the management of breast cancer patients. Eur J Cancer. 2008;44:353–365
- Aapro M, Schwenkglenks M, Lyman G, et al. Reduced incidence of febrile neutropenia and related complications in elderly breast cancer patients receiving chemotherapy with pegfilgrastim primary prophylaxis versus current practice neutropenia management — results from an integrated analysis. 30th Annual San Antonio Breast Cancer Symposium, 2007; poster 1088.
- International Society of Geriatric Oncology (SIOG) clinical practice recommendations for the use of bisphosphonates in elderly patients. Eur J Cancer. 2007;43:852–858
- . Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel. Ann Oncol. 2008;19:420–432
- Guidance for the management of breast cancer treatment-induced bone loss: A consensus position statement from a UK Expert Group. Cancer Treat Rev. 2008;34(Suppl 1):S3–S18
- . Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study. J Clin Oncol. 2005;23:8597–8605
- Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. J Clin Oncol. 2007;25:3808–3815
- A correlative study of cardiac biomarkers and left ventricular ejection fraction (LVEF) from N9831, a phase III randomized trial of chemotherapy and trastuzumab as adjuvant therapy for HER2-positive breast cancer. J Clin Oncol. 2007;25(18 Suppl):22s
- Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/cyclophosphamide (AC)
→
paclitaxel (T) vs. AC
→
T with trastuzumab (H). J Clin Oncol. 2007;25(18 Suppl):964s - Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 Adjuvant Breast Cancer Trial. J Clin Oncol. 2008;26:1231–1238
- Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol. 2007;25:3859–3865
- . Cardiac safety experience in 3558 patients treated with lapatinib. Ann Oncol. 2006;17(Suppl 9):ix70
- Baxter NN, Durham SB, Phillips KA, et al. Risk of dementia in older breast cancer survivors: a population-based cohort study of the effects of chemotherapy. 30th Annual San Antonio Breast Cancer Symposium, 2007; poster 1075.
- A phase III randomised comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on tratsuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat. 2008;Jan 11;(Epub ahead of print)
- Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med. 2005;353:1659–1672
- Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007;357:2666–2676
- SofEA (Study of Faslodex, Exemestane and Arimidex). Trial protocol, version 6 (17 November 2006).
- Step by step development of clinical care pathways for older cancer patients: necessary or desirable?. Eur J Cancer. 2007;43:2170–2178
PII: S0936-6555(08)00454-8
doi: 10.1016/j.clon.2008.11.015
© 2008 The Royal College of Radiologists. Published by Elsevier Inc. All rights reserved.
« Previous
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Clinical Oncology
Volume 21, Issue 2
, Pages 118-130
, March 2009
