Clinical Oncology
Volume 22, Issue 1 , Pages 39-45 , February 2010

Adjuvant Regional Irradiation after Breast-conserving Therapy for Early Stage Breast Cancer: a Survey of Canadian Radiation Oncologists

  • S. Clavel

      Affiliations

    • Corresponding Author InformationAuthor for correspondence: S. Clavel, Department of Radiation Oncology, Centre hospitalier de l'Université de Montréal, 1560 Sherbrooke East, Montréal (Qc) H2L 4M1, Canada. Tel.: +1 514 890 8254; Fax: +1 514 412 7537.
    • ,
  • I. Roy
    • ,
  • J.-F. Carrier
    • ,
  • P. Rousseau
    • ,
  • M.-A. Fortin

Received 9 March 2009 ,Revised 10 September 2009 ,Accepted 14 September 2009.

References 

  1. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–1241
  2. van Dongen JA, Voogd AC, Fentiman IS, et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst. 2000;92:1143–1150
  3. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–1232
  4. Vinh-Hung V, Verschraegen C. Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality. J Natl Cancer Inst. 2004;96:115–121
  5. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;366:2087–2106
  6. Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med. 1997;337:956–962
  7. Overgaard M, Hansen PS, Overgaard J, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med. 1997;337:949–955
  8. Williams MV, Summers ET, Drinkwater K, et al. Radiotherapy dose fractionation, access and waiting times in the countries of the UK in 2005. Clin Oncol (R Coll Radiol). 2007;19:273–286
  9. Truong PT, Olivotto IA, Whelan TJ, et al. Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy. CMAJ. 2004;170:1263–1273
  10. Recht A, Edge SB, Solin LJ, et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2001;19:1539–1569
  11. Wallgren A, Bonetti M, Gelber RD, et al. Risk factors for locoregional recurrence among breast cancer patients: results from International Breast Cancer Study Group Trials I through VII. J Clin Oncol. 2003;21:1205–1213
  12. Fortin A, Dagnault A, Blondeau L, et al. The impact of the number of excised axillary nodes and of the percentage of involved nodes on regional nodal failure in patients treated by breast-conserving surgery with or without regional irradiation. Int J Radiat Oncol Biol Phys. 2006;65:33–39
  13. Woodward WA, Vinh-Hung V, Ueno NT, et al. Prognostic value of nodal ratios in node-positive breast cancer. J Clin Oncol. 2006;24:2910–2916
  14. Truong PT, Woodward WA, Thames HD, et al. The ratio of positive to excised nodes identifies high-risk subsets and reduces inter-institutional differences in locoregional recurrence risk estimates in breast cancer patients with 1-3 positive nodes: an analysis of prospective data from British Columbia and the M.D. Anderson Cancer Center. Int J Radiat Oncol Biol Phys. 2007;68:59–65
  15. Axelsson CK, During M, Christiansen PM, et al. Impact on regional recurrence and survival of axillary surgery in women with node-negative primary breast cancer. Br J Surg. 2009;96:40–46
  16. Taghian A, Jagsi R, Makris A, et al. Results of a survey regarding irradiation of internal mammary chain in patients with breast cancer: practice is culture driven rather than evidence based. Int J Radiat Oncol Biol Phys. 2004;60:706–714
  17. Ceilley E, Jagsi R, Goldberg S, et al. Radiotherapy for invasive breast cancer in North America and Europe: results of a survey. Int J Radiat Oncol Biol Phys. 2005;61:365–373
  18. Pierce LJ, Moughan J, White J, et al. 1998-1999 patterns of care study process survey of national practice patterns using breast-conserving surgery and radiotherapy in the management of stage I-II breast cancer. Int J Radiat Oncol Biol Phys. 2005;62:183–192
  19. Hui Z, Li Y, Yu Z, et al. Survey on use of postmastectomy radiotherapy for breast cancer in China. Int J Radiat Oncol Biol Phys. 2006;66:1135–1142
  20. Vu TT, Pignol JP, Rakovitch E, et al. Variability in radiation oncologists' opinion on the indication of a bolus in post-mastectomy radiotherapy: an international survey. Clin Oncol (R Coll Radiol). 2007;19:115–119
  21. Truong PT, Lesperance M, Culhaci A, et al. Patient subsets with T1-T2, node-negative breast cancer at high locoregional recurrence risk after mastectomy. Int J Radiat Oncol Biol Phys. 2005;62:175–182
  22. Tai P, Joseph K, Sadikov E, et al. Nodal ratios in node-positive breast cancer–long-term study to clarify discrepancy of role of supraclavicular and axillary regional radiotherapy. Int J Radiat Oncol Biol Phys. 2007;68:662–666
  23. Freedman RA, He Y, Winer EP, et al. Trends in racial and age disparities in definitive local therapy of early-stage breast cancer. J Clin Oncol. 2009;27:713–719
  24. Grills IS, Kestin LL, Goldstein N, et al. Risk factors for regional nodal failure after breast-conserving therapy: regional nodal irradiation reduces rate of axillary failure in patients with four or more positive lymph nodes. Int J Radiat Oncol Biol Phys. 2003;56:658–670
  25. Mignano JE, Gage I, Piantadosi S, et al. Local recurrence after mastectomy in patients with T3pN0 breast carcinoma treated without postoperative radiation therapy. Am J Clin Oncol. 2007;30:466–472
  26. McCammon R, Finlayson C, Schwer A, et al. Impact of postmastectomy radiotherapy in T3N0 invasive carcinoma of the breast: a Surveillance, Epidemiology, and End Results database analysis. Cancer. 2008;113:683–689
  27. Le MG, Arriagada R, de Vathaire F, et al. Can internal mammary chain treatment decrease the risk of death for patients with medial breast cancers and positive axillary lymph nodes?. Cancer. 1990;66:2313–2318
  28. Buchholz TA. Internal mammary lymph nodes: to treat or not to treat. Int J Radiat Oncol Biol Phys. 2000;46:801–803
  29. Chen RC, Lin NU, Golshan M, et al. Internal Mammary Nodes in Breast Cancer: Diagnosis and Implications for Patient Management–A Systematic Review. J Clin Oncol. 2008;
  30. Truong PT, Jones SO, Kader HA, et al. Patients with t1 to t2 breast cancer with one to three positive nodes have higher local and regional recurrence risks compared with node-negative patients after breast-conserving surgery and whole-breast radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:357–364
  31. Fortin A, Dagnault A, Larochelle M, et al. Impact of locoregional radiotherapy in node-positive patients treated by breast-conservative treatment. Int J Radiat Oncol Biol Phys. 2003;56:1013–1022
  32. Kellerman SE, Herold J. Physician response to surveys. A review of the literature. Am J Prev Med. 2001;20:61–67

PII: S0936-6555(09)00326-4

doi: 10.1016/j.clon.2009.09.026

Clinical Oncology
Volume 22, Issue 1 , Pages 39-45 , February 2010

Article Tools