Clinical Oncology
Volume 22, Issue 3 , Pages 208-221 , April 2010

The Effect of Physical Exercise on Cancer-related Fatigue during Cancer Treatment: a Meta-analysis of Randomised Controlled Trials

  • M.J. Velthuis

      Affiliations

    • Comprehensive Cancer Center Middle Netherlands, Utrecht, the Netherlands
    • Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands
    • Corresponding Author InformationAuthor for correspondence: M. J. Velthuis, Comprehensive Cancer Center Middle Netherlands, PO Box 19079, 3501 DB Utrecht, the Netherlands. Tel: +31-30-233-7091/+31-30-233-8060; Fax: +31-30-233-8079.
  • ,
  • S.C. Agasi-Idenburg

      Affiliations

    • The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands
    • University of Applied Sciences, Utrecht, the Netherlands
  • ,
  • G. Aufdemkampe

      Affiliations

    • University of Applied Sciences, Utrecht, the Netherlands
    • University of Applied Sciences, Research Group Lifestyle and Health, Utrecht, the Netherlands
  • ,
  • H.M. Wittink

      Affiliations

    • University of Applied Sciences, Utrecht, the Netherlands
    • University of Applied Sciences, Research Group Lifestyle and Health, Utrecht, the Netherlands

Received 1 September 2009 ,Revised 3 December 2009 ,Accepted 8 December 2009.

References 

  1. Signaleringscommissie Kanker van KWF Kankerbestrijding. Kanker in Nederland, Trends prognoses en implicaties voor zorgvraag. Report of the Dutch Cancer Society, 2004.
  2. Armes J, Krishnasamy M, Higginson I. Fatigue in cancer. Oxford: Oxford University Press; 2005;
  3. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Cancer-related fatigue. version 1. Fort Washington: National Comprehensive Cancer Network, 2009.
  4. Lucia A, Earnest C, Perez M. Cancer-related fatigue: can exercise physiology assist oncologists?. Lancet Oncol. 2003;4:616–625
  5. Wagner LI, Cella D. Fatigue and cancer: causes, prevalence and treatment approaches. Br J Cancer. 2004;91:822–828
  6. McNeely ML, Campbell KL, Rowe BH, Klassen TP, Mackey JR, Courneya KS. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ. 2006;175:34–41
  7. Markes M, Brockow T, Resch KL. Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Database Syst Rev. 2006;CD005001
  8. Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G. Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol. 2005;23:3830–3842
  9. Watson T, Mock V. Exercise as an intervention for cancer-related fatigue. Phys Ther. 2004;84:736–743
  10. Ahlberg K, Ekman T, Gaston-Johansson F, Mock V. Assessment and management of cancer-related fatigue in adults. Lancet. 2003;362:640–650
  11. Cramp F, Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2008;CD006145
  12. Irwin ML, McTiernan A, Bernstein L, et al. Physical activity levels among breast cancer survivors. Med Sci Sports Exerc. 2004;36:1484–1491
  13. Astrand PO, Rodahl K, Dahl HA, Stromme SB. Textbook of work physiology: physiological basis of exercise. Idaho: Human Kinetics; 2003;
  14. Kujala UM. Evidence for exercise therapy in the treatment of chronic disease based on at least three randomized controlled trials — summary of published systematic reviews. Scand J Med Sci Sports. 2004;14:339–345
  15. Taylor NF, Dodd KJ, Shields N, Bruder A. Therapeutic exercise in physiotherapy practice is beneficial: a summary of systematic reviews 2002–2005. Aust J Physiother. 2007;53:7–16
  16. Pedersen BK, Saltin B. Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports. 2006;16(Suppl. 1):3–63
  17. Hayes SC, Spence RR, Galvao DA, Newton RU. Australian association for exercise and sport science position stand: optimising cancer outcomes through exercise. J Sci Med Sport. 2009;12:428–434
  18. Haynes RB, McKibbon KA, Wilczynski NL, Walter SD, Werre SR. Optimal search strategies for retrieving scientifically strong studies of treatment from medline: analytical survey. Br Med J. 2005;330:1179
  19. Courneya KS. Exercise interventions during cancer treatment: biopsychosocial outcomes. Exerc Sport Sci Rev. 2001;29:60–64
  20. Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83:713–721
  21. Olivo SA, Macedo LG, Gadotti IC, Fuentes J, Stanton T, Magee DJ. Scales to assess the quality of randomized controlled trials: a systematic review. Phys Ther. 2008;88:156–175
  22. Van Peppen RP, Kwakkel G, Wood-Dauphinee S, Hendriks HJ, Van der Wees PJ, Dekker J. The impact of physical therapy on functional outcomes after stroke: what's the evidence?. Clin Rehabil. 2004;18:833–862
  23. Cohen J. Statistical power analysis for the behavioral sciences. Hillsdale: Lawrence Erlbaum Associates; 1988;
  24. Courneya KS, Segal RJ, Gelmon K, et al. Six-month follow-up of patient-rated outcomes in a randomized controlled trial of exercise training during breast cancer chemotherapy. Cancer Epidemiol Biomarkers Prev. 2007;16:2572–2578
  25. Crowley S. The effect of a structured exercise program on fatigue, strength, endurance, physical self-efficacy, and functional wellness in women with early stage breast cancer. Ann Arbor: University of Michigan; 2003;
  26. Drouin J, Krause S, Orr J. Effects of aerobic exercise training son peak aerobic capacity, fatigue, and psychological factors during radiation for breast cancer. Rehabil Oncol. 2005;23:11–17
  27. Headley JA, Ownby KK, John LD. The effect of seated exercise on fatigue and quality of life in women with advanced breast cancer. Oncol Nurs Forum. 2004;31:977–983
  28. Mock V, Burke MB, Sheehan P, et al. A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy. Oncol Nurs Forum. 1994;21:899–907
  29. Mock V, Pickett M, Ropka ME, et al. Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract. 2001;9:119–127
  30. Mock V, Frangakis C, Davidson NE, et al. Exercise manages fatigue during breast cancer treatment: a randomized controlled trial. Psychooncology. 2005;14:464–477
  31. Payne JK, Held J, Thorpe J, Shaw H. Effect of exercise on biomarkers, fatigue, sleep disturbances, and depressive symptoms in older women with breast cancer receiving hormonal therapy. Oncol Nurs Forum. 2008;35:635–642
  32. Campbell A, Mutrie N, White F, McGuire F, Kearney N. A pilot study of a supervised group exercise programme as a rehabilitation treatment for women with breast cancer receiving adjuvant treatment. Eur J Oncol Nurs. 2005;9:56–63
  33. Courneya KS, Segal RJ, Mackey JR, et al. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol. 2007;25:4396–4404
  34. Hwang JH, Chang HJ, Shim YH, et al. Effects of supervised exercise therapy in patients receiving radiotherapy for breast cancer. Yonsei Med J. 2008;49:443–450
  35. Mutrie N, Campbell AM, Whyte F, et al. Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial. Br Med J. 2007;334:517
  36. Battaglini CL, Mihalik JP, Bottaro M, et al. Effect of exercise on the caloric intake of breast cancer patients undergoing treatment. Braz J Med Biol Res. 2008;41:709–715
  37. Coleman EA, Coon S, Hall-Barrow J, Richards K, Gaylor D, Stewart B. Feasibility of exercise during treatment for multiple myeloma. Cancer Nurs. 2003;26:410–419
  38. Chang PH, Lai YH, Shun SC, et al. Effects of a walking intervention on fatigue-related experiences of hospitalized acute myelogenous leukemia patients undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manage. 2008;35:524–534
  39. Monga U, Garber SL, Thornby J, et al. Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Arch Phys Med Rehabil. 2007;88:1416–1422
  40. Segal RJ, Reid RD, Courneya KS, et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol. 2003;21:1653–1659
  41. Segal RJ, Reid RD, Courneya KS, et al. Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol. 2009;27:344–351
  42. Windsor PM, Nicol KF, Potter J. A randomized, controlled trial of aerobic exercise for treatment-related fatigue in men receiving radical external beam radiotherapy for localized prostate carcinoma. Cancer. 2004;101:550–557
  43. Bendermacher BL, Willigendael EM, Teijink JA, Prins MH. Supervised exercise therapy versus non-supervised exercise therapy for intermittent claudication. Cochrane Database Syst Rev. 2006;CD005263
  44. Ashworth NL, Chad KE, Harrison EL, Reeder BA, Marshall SC. Home versus center based physical activity programs in older adults. Cochrane Database Syst Rev. 2005;CD004017
  45. Oldervoll LM, Loge JH, Paltiel H, et al. Are palliative cancer patients willing and able to participate in a physical exercise program?. Palliat Support Care. 2005;3:281–287
  46. Cella D, Eton DT, Lai JS, Peterman AH, Merkel DE. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage. 2002;24:547–561
  47. World Health Organization . International classification of functioning, disability and health: ICF. Geneva: World Health Organization; 2001;
  48. Gilchrist LS, Galantino ML, Wampler M, Marchese VG, Morris GS, Ness KK. A framework for assessment in oncology rehabilitation. Phys Ther. 2009;89:286–306

PII: S0936-6555(09)00411-7

doi: 10.1016/j.clon.2009.12.005

Clinical Oncology
Volume 22, Issue 3 , Pages 208-221 , April 2010