The Value of Periodic Follow-up in the Detection of Recurrences after Radical Treatment in Locally Advanced Head and Neck Cancer
Received 19 June 2009; received in revised form 14 April 2010; accepted 12 May 2010. published online 22 July 2010. Corrected Proof
Abstract
Aims
To determine the value of routine follow-up in detecting and salvaging recurrence after radical treatment of locally advanced head and neck squamous cell carcinoma and to identify clinical or pathological prognostic factors that predicted for survival.
Materials and methods
A retrospective medical chart review was conducted at the Odette Cancer Centre between January 2000 and May 2006. Two hundred and twenty-three patients with advanced (stage III or IV) squamous cell carcinoma of the head and neck who were treated with curative intent were reviewed. Recurrences were divided into local, regional or distant recurrences. The detection method for each recurrence was categorised as self or physician detected. A self-detected recurrence arose from symptoms that led to investigations that confirmed a recurrence (even if initiated at the time of a routine visit), whereas a physician-detected recurrence was found during the routine follow-up examination and was asymptomatic.
Results
There was no evidence to suggest a significant improvement in disease-free or overall survival in the physician-detected versus patient-detected groups. Regional and distant recurrences were only detected by physicians in one-fifth of cases and, overall, patients self-detected their own recurrence in two-thirds of the cases that experienced disease progression within the sample. Of the 12 clinical/pathological variables considered, only the response to treatment and perineural invasion were associated with survival.
Conclusions
Current surveillance methods do not appear to improve cancer control in the stage III/IV head and neck squamous cell carcinoma population. However, technological advances and biomarker development may lead to surveillance technique enhancements. Also, post-treatment follow-up remains important for the evaluation of treatment results, emotional support and management of late complications. Among the clinical and pathological factors considered, only the treatment response and perineural invasion predicted survival.
‡Department of Biostatistics, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
§Department of Otolaryngology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Author for correspondence: I. Poon, Department of Radiation Oncology, University of Toronto, Odette Cancer Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5. Tel: +1-416-480-4951; Fax: +1-416-480-6002.
ABSTRACT