Clinical Oncology
Volume 22, Issue 7 , Pages 590-601 , September 2010

Substantial Improvement in UK Cervical Cancer Survival with Chemoradiotherapy: Results of a Royal College of Radiologists’ Audit

  • C.L. Vale

      Affiliations

    • Meta-analysis Group, MRC Clinical Trials Unit, London, UK
    • ,
  • J.F. Tierney

      Affiliations

    • Meta-analysis Group, MRC Clinical Trials Unit, London, UK
    • ,
  • S.E. Davidson

      Affiliations

    • The Christie NHS Foundation Trust, Manchester, UK
    • ,
  • K.J. Drinkwater

      Affiliations

    • The Royal College of Radiologists, London, UK
    • ,
  • P. Symonds

      Affiliations

    • Department of Cancer Studies & Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    • Corresponding Author InformationAuthor for correspondence: P. Symonds, Department of Cancer Studies & Molecular Medicine, Level 2, Osborne Building, Leicester Royal Infirmary, Leicester LE1 5WW, UK. Tel: +44-116-258-6294; Fax: +44-116-258-7599.

Received 21 January 2010 ,Revised 7 April 2010 ,Accepted 26 April 2010.

References 

  1. Cancer Research UK . UK cervical cancer incidence statistics. 2009;
  2. Quinn MJ, Babb P, Jones J, Allen E. Effect of screening on incidence of and mortality from cervix cancer in England: evaluation based on routinely collected statistics. Br Med J. 1999;318:904–908
  3. Schrijivers CTM, Mackenbach JP, Lutz JM, Quinn MJ, Coleman MP. Deprivation, stage at diagnosis and cancer survival. Int J Cancer. 1995;63:324–329
  4. National Cancer Institute. NCI issues clinical announcement on cervical cancer: chemotherapy plus radiation improves survival. 1999;99:
  5. Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. New Engl J Med. 1999;340:1144–1153
  6. Whitney CW, Sause W, Bundy BN, et al. Randomised comparison of fluorouracil plus cisplatin versus hydroxyurea in stage IIB/IVA in carcinoma of the cervix. J Clin Oncol. 1999;17:1339–1348
  7. Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. New Engl J Med. 1999;340:1154–1161
  8. Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. New Engl J Med. 1999;340:1137–1143
  9. Peters WA, Liu PY, Barrett RGW, et al. Cisplatin, 5-fluorouracil plus radiation therapy are superior to radiation therapy as adjunctive therapy in high risk, early stage carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: report of a phase III inter group study. Gynecol Oncol. 1999;72(3):443
  10. Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol. 2008;26(35):5802–5812
  11. Tan LT, Zahra M. Long-term survival and late toxicity after chemo-radiotherapy for cervical cancer – the Addenbrooke’s experience. Clin Oncol. 2008;20:358–364
  12. Spensley S, Hunter RD, Livsey JE, Swindell R, Davidson SE. Clinical outcome for chemoradiotherapy in carcinoma of the cervix. Clin Oncol. 2009;21(1):49–55
  13. Goonatillake S, Khong R, Hoskin P. Chemoradiation in gynaecological cancer. Clin Oncol. 2009;21(7):566–572
  14. Chassagne D, Sismondi P, Horiot JC, et al. A glossary for reporting complications of treatment in gynecological cancers. Radiother Oncol. 1993;26:195–202
  15. Denton AS, Bond SJ, Matthews SJ, Bentzen SM, Maher EJ UK Link Gynaecology–Oncology Group. National audit of the management and outcomes of carcinoma of the cervix treated with radiotherapy in 1993. Clin Oncol. 2000;12:347–353
  16. Quinn M, Benedet J, Odicino F, et al. Carcinoma of the cervix uteri. FIGO 6th annual report on the results of treatment in gynaecological cancer. Int J Gynaecol Obstet. 2006;95(Suppl. 1):S43–S103
  17. Davidson SE, Burns MP, Routledge JA, Swindell R, Bentzen SM, West CML. Assessment of morbidity in carcinoma of the cervix: a comparison of the LENT SOMA scales and the Franco-Italian glossary. Radiother Oncol. 2003;69:195–200
  18. Davidson SE, Trotti A, Ataman OU, et al. Improving the capture of adverse event data in clinical trials: the role of the International Atomic Energy Agency. Int J Radiat Oncol Biol Phys. 2007;69:1218–1221

PII: S0936-6555(10)00198-6

doi: 10.1016/j.clon.2010.06.002

Clinical Oncology
Volume 22, Issue 7 , Pages 590-601 , September 2010

Article Tools

* Image Usage & Resolution