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History of Depression in Lung Cancer Patients: Impact of Delay

  • M. Iachina
    Correspondence
    Author for correspondence: M. Iachina, Center for Clinical Epidemiology, Odense University Hospital, Sdr. Boulevard 29, Entrance 216, Ground Floor East, DK-5000 Odense C, Denmark. Tel: +45-21158110.
    Affiliations
    Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark

    The Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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  • M.M. Brønserud
    Affiliations
    Department of Thoracic Surgery, Odense University Hospital, Odense, Denmark

    OPEN, Odense Patient Data Exploratory Network, Odense University Hospital/Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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  • E. Jakobsen
    Affiliations
    Department of Thoracic Surgery, Odense University Hospital, Odense, Denmark

    OPEN, Odense Patient Data Exploratory Network, Odense University Hospital/Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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  • O. Trosko
    Affiliations
    Research Unit of Psychiatry, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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  • A. Green
    Affiliations
    OPEN, Odense Patient Data Exploratory Network, Odense University Hospital/Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Published:April 14, 2017DOI:https://doi.org/10.1016/j.clon.2017.03.014

      Highlights

      • Anamnestic depression is not associated with a delay in diagnostic evaluation.
      • Patients with periodic anamnestic depression have a lower treatment rate.

      Abstract

      Aims

      To examine the influence of a history of depression in the process of diagnostic evaluation and the choice of treatment in lung cancer.

      Materials and methods

      The analysis was based on all patients with non-small cell lung cancer who were registered in 2008–2014; in total, 27 234 patients. To estimate the effect of depression on the diagnostic process and the choice of treatment in lung cancer we fitted a logistic regression model and a Cox regression model adjusting for age, gender, resection and stage.

      Results

      Depression in a patient's anamnesis had no significant effect on the delay in diagnostic evaluation (hazard ratio = 0.99 with 95% confidence interval 0.90; 1.09). Patients with a history of periodic depression had a 33% lower treatment rate (odds ratio = 0.66 with 95% confidence interval 0.51; 0.85) than patients without a history of depression.

      Conclusions

      Our study shows that patients with a history of periodic depression need special attention when diagnosed with lung cancer.

      Key words

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